Customized solid supports for small-molecule synthesis: Effects of crosslinking structure and degree

Michael D. Price; Jennifer L. Radosevich; Mark J. Kurth; Neil E. Schore

doi:10.1016/S1381-5148(02)00222-5

Customized solid supports for small-molecule synthesis: Effects of crosslinking structure and degree

Michael D. Price, Jennifer L. Radosevich, Mark J. Kurth, Neil E. Schore

Chemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Divinylbenzene (DVB) and diethylene glycol bis(4-vinylbenzyl) ether (DEG) were used as crosslinkers in the preparation of four resins of mixed micro- and macroporous character and differing polarity to examine the effects of crosslinker structure and macroporosity. The Suzuki coupling process was used as the probe reaction for this purpose. Results with 2% DVB, 2% DEG, 5% DEG and 15% DEG indicate that the DEG-crosslinked resins are somewhat better suited for this process, although the degree of crosslinking appears to have only minimal effect of degree of conversion to product.

Original language	English (US)
Pages (from-to)	131-137
Number of pages	7
Journal	Reactive and Functional Polymers
Volume	55
Issue number	2
DOIs	https://doi.org/10.1016/S1381-5148(02)00222-5
State	Published - Apr 2003

Keywords

Coupling reaction
Crosslinker
Polymer
Solid-phase synthesis
Suzuki reaction

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics

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10.1016/S1381-5148(02)00222-5

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title = "Customized solid supports for small-molecule synthesis: Effects of crosslinking structure and degree",

abstract = "Divinylbenzene (DVB) and diethylene glycol bis(4-vinylbenzyl) ether (DEG) were used as crosslinkers in the preparation of four resins of mixed micro- and macroporous character and differing polarity to examine the effects of crosslinker structure and macroporosity. The Suzuki coupling process was used as the probe reaction for this purpose. Results with 2% DVB, 2% DEG, 5% DEG and 15% DEG indicate that the DEG-crosslinked resins are somewhat better suited for this process, although the degree of crosslinking appears to have only minimal effect of degree of conversion to product.",

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AU - Kurth, Mark J.

AU - Schore, Neil E.

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AB - Divinylbenzene (DVB) and diethylene glycol bis(4-vinylbenzyl) ether (DEG) were used as crosslinkers in the preparation of four resins of mixed micro- and macroporous character and differing polarity to examine the effects of crosslinker structure and macroporosity. The Suzuki coupling process was used as the probe reaction for this purpose. Results with 2% DVB, 2% DEG, 5% DEG and 15% DEG indicate that the DEG-crosslinked resins are somewhat better suited for this process, although the degree of crosslinking appears to have only minimal effect of degree of conversion to product.

KW - Coupling reaction

KW - Crosslinker

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KW - Suzuki reaction

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