Customized solid supports for small-molecule synthesis: Effects of crosslinking structure and degree

Michael D. Price, Jennifer L. Radosevich, Mark J. Kurth, Neil E. Schore

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Divinylbenzene (DVB) and diethylene glycol bis(4-vinylbenzyl) ether (DEG) were used as crosslinkers in the preparation of four resins of mixed micro- and macroporous character and differing polarity to examine the effects of crosslinker structure and macroporosity. The Suzuki coupling process was used as the probe reaction for this purpose. Results with 2% DVB, 2% DEG, 5% DEG and 15% DEG indicate that the DEG-crosslinked resins are somewhat better suited for this process, although the degree of crosslinking appears to have only minimal effect of degree of conversion to product.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalReactive and Functional Polymers
Volume55
Issue number2
DOIs
StatePublished - Apr 2003

Keywords

  • Coupling reaction
  • Crosslinker
  • Polymer
  • Solid-phase synthesis
  • Suzuki reaction

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

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