Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins

David Segal; Carlos F. Barbas

doi:10.1016/S0958-1669(01)00272-5

Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins

David Segal, Carlos F. Barbas

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

Original language	English (US)
Pages (from-to)	632-637
Number of pages	6
Journal	Current Opinion in Biotechnology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/S0958-1669(01)00272-5
State	Published - Dec 1 2001
Externally published	Yes

ASJC Scopus subject areas

Biotechnology

Access to Document

10.1016/S0958-1669(01)00272-5

Fingerprint Dive into the research topics of 'Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins'. Together they form a unique fingerprint.

Cite this

@article{acde89e0a92a4646a5da53fb2ea4b692,

title = "Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins",

abstract = "Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.",

author = "David Segal and Barbas, {Carlos F.}",

year = "2001",

month = dec,

day = "1",

doi = "10.1016/S0958-1669(01)00272-5",

language = "English (US)",

volume = "12",

pages = "632--637",

journal = "Current Opinion in Biotechnology",

issn = "0958-1669",

publisher = "Elsevier Limited",

number = "6",

}

TY - JOUR

T1 - Custom DNA-binding proteins come of age

T2 - Polydactyl zinc-finger proteins

AU - Segal, David

AU - Barbas, Carlos F.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

AB - Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

UR - http://www.scopus.com/inward/record.url?scp=0035712253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035712253&partnerID=8YFLogxK

U2 - 10.1016/S0958-1669(01)00272-5

DO - 10.1016/S0958-1669(01)00272-5

M3 - Article

C2 - 11849947

AN - SCOPUS:0035712253

VL - 12

SP - 632

EP - 637

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

SN - 0958-1669

IS - 6

ER -