Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins

David Segal, Carlos F. Barbas

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

Original languageEnglish (US)
Pages (from-to)632-637
Number of pages6
JournalCurrent Opinion in Biotechnology
Volume12
Issue number6
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology

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