Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins

David Segal; Carlos F. Barbas

doi:10.1016/S0958-1669(01)00272-5

Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins

David Segal, Carlos F. Barbas

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

Original language	English (US)
Pages (from-to)	632-637
Number of pages	6
Journal	Current Opinion in Biotechnology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/S0958-1669(01)00272-5
State	Published - Dec 1 2001
Externally published	Yes

ASJC Scopus subject areas

Biotechnology

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10.1016/S0958-1669(01)00272-5

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title = "Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins",

abstract = "Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.",

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AB - Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

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Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins

Abstract

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