Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins

David Segal, Carlos F. Barbas

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

Original languageEnglish (US)
Pages (from-to)632-637
Number of pages6
JournalCurrent Opinion in Biotechnology
Issue number6
StatePublished - Dec 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology


Dive into the research topics of 'Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins'. Together they form a unique fingerprint.

Cite this