Abstract
Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 632-637 |
| Number of pages | 6 |
| Journal | Current Opinion in Biotechnology |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biotechnology
Cite this
Custom DNA-binding proteins come of age : Polydactyl zinc-finger proteins. / Segal, David; Barbas, Carlos F.
In: Current Opinion in Biotechnology, Vol. 12, No. 6, 01.12.2001, p. 632-637.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Custom DNA-binding proteins come of age
T2 - Polydactyl zinc-finger proteins
AU - Segal, David
AU - Barbas, Carlos F.
PY - 2001/12/1
Y1 - 2001/12/1
N2 - Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.
AB - Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035712253&partnerID=8YFLogxK
U2 - 10.1016/S0958-1669(01)00272-5
DO - 10.1016/S0958-1669(01)00272-5
M3 - Article
C2 - 11849947
AN - SCOPUS:0035712253
VL - 12
SP - 632
EP - 637
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
SN - 0958-1669
IS - 6
ER -