Current Understanding of the Genetics of Intervertebral Disc Degeneration

Research output: Contribution to journalReview article

Abstract

Premature degeneration of the intervertebral disc and its association with specific chondrodystrophic dog breeds has been recognized for over a century. Several lines of evidence including disease breed predisposition, studies suggesting heritability of premature intervertebral disc degeneration (IVDD) and association of a dog chromosome 12 (CFA 12) locus with intervertebral disc calcification have strongly supported a genetic component in IVDD in dogs. Recent studies documenting association of IVDD with an overexpressing FGF4 retrogene on CFA 12 have opened up new areas of investigation to further define the pathophysiology of premature IVDD. While preliminary data from studies investigating FGF4 retrogenes in IVDD implicate FGF4 overexpression as a major disease factor, they have also highlighted knowledge gaps in our understanding of intervertebral disc herniation which is a complex and multifactorial disease process.

Original languageEnglish (US)
Article number431
JournalFrontiers in Veterinary Science
Volume7
DOIs
StatePublished - Jul 24 2020

Keywords

  • chondrodystrophy
  • fibroblast growth factor 4
  • heritable
  • intervertebral disc degeneration
  • retrogene

ASJC Scopus subject areas

  • veterinary(all)

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