Current Treatment Options for Primary Biliary Cholangitis

Kimberly A. Wong, Runalia Bahar, Chung H. Liu, Christopher Bowlus

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Primary biliary cholangitis is a progressive, autoimmune disease of the interlobular bile ducts, leading to secondary damage of hepatocytes that may progress to cirrhosis and liver failure. Until recently, the only approved treatment was ursodeoxycholic acid. However, 40% of patients do not have an adequate response. Obeticholic acid was approved for treatment as add-on therapy in this group of patients. Off-label use of fibrates has also been reported to be effective. Several new therapies are in development and may further add to the treatment options available to patients with primary biliary cholangitis.

Original languageEnglish (US)
JournalClinics in Liver Disease
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Cholangitis
Off-Label Use
Fibric Acids
Ursodeoxycholic Acid
Liver Failure
Therapeutics
Group Psychotherapy
Bile Ducts
Autoimmune Diseases
Hepatocytes
Fibrosis

Keywords

  • Autoimmune liver disease
  • Bile acids
  • Farnesoid X receptor
  • Therapy

ASJC Scopus subject areas

  • Hepatology

Cite this

Current Treatment Options for Primary Biliary Cholangitis. / Wong, Kimberly A.; Bahar, Runalia; Liu, Chung H.; Bowlus, Christopher.

In: Clinics in Liver Disease, 01.01.2018.

Research output: Contribution to journalArticle

@article{661548c53efb4bdc8f0ff27bda6774c2,
title = "Current Treatment Options for Primary Biliary Cholangitis",
abstract = "Primary biliary cholangitis is a progressive, autoimmune disease of the interlobular bile ducts, leading to secondary damage of hepatocytes that may progress to cirrhosis and liver failure. Until recently, the only approved treatment was ursodeoxycholic acid. However, 40{\%} of patients do not have an adequate response. Obeticholic acid was approved for treatment as add-on therapy in this group of patients. Off-label use of fibrates has also been reported to be effective. Several new therapies are in development and may further add to the treatment options available to patients with primary biliary cholangitis.",
keywords = "Autoimmune liver disease, Bile acids, Farnesoid X receptor, Therapy",
author = "Wong, {Kimberly A.} and Runalia Bahar and Liu, {Chung H.} and Christopher Bowlus",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.cld.2018.03.003",
language = "English (US)",
journal = "Clinics in Liver Disease",
issn = "1089-3261",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Current Treatment Options for Primary Biliary Cholangitis

AU - Wong, Kimberly A.

AU - Bahar, Runalia

AU - Liu, Chung H.

AU - Bowlus, Christopher

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Primary biliary cholangitis is a progressive, autoimmune disease of the interlobular bile ducts, leading to secondary damage of hepatocytes that may progress to cirrhosis and liver failure. Until recently, the only approved treatment was ursodeoxycholic acid. However, 40% of patients do not have an adequate response. Obeticholic acid was approved for treatment as add-on therapy in this group of patients. Off-label use of fibrates has also been reported to be effective. Several new therapies are in development and may further add to the treatment options available to patients with primary biliary cholangitis.

AB - Primary biliary cholangitis is a progressive, autoimmune disease of the interlobular bile ducts, leading to secondary damage of hepatocytes that may progress to cirrhosis and liver failure. Until recently, the only approved treatment was ursodeoxycholic acid. However, 40% of patients do not have an adequate response. Obeticholic acid was approved for treatment as add-on therapy in this group of patients. Off-label use of fibrates has also been reported to be effective. Several new therapies are in development and may further add to the treatment options available to patients with primary biliary cholangitis.

KW - Autoimmune liver disease

KW - Bile acids

KW - Farnesoid X receptor

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=85047222695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047222695&partnerID=8YFLogxK

U2 - 10.1016/j.cld.2018.03.003

DO - 10.1016/j.cld.2018.03.003

M3 - Article

C2 - 30259848

AN - SCOPUS:85047222695

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

SN - 1089-3261

ER -