Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop

Pooja Hingorani, Katherine Janeway, Brian D. Crompton, Cigall Kadoch, Crystal L. Mackall, Javed Khan, Jack F. Shern, Joshua Schiffman, Lisa Mirabello, Sharon A. Savage, Marc Ladanyi, Paul Meltzer, Carol J. Bult, Peter C. Adamson, Philip J. Lupo, Rajen Mody, Steven G. DuBois, D. Williams Parsons, Chand Khanna, Ching LauDouglas S. Hawkins, R Randall, Malcolm Smith, Poul H. Sorensen, Sharon E. Plon, Stephen X. Skapek, Stephen Lessnick, Richard Gorlick, Damon R. Reed

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time. However, much remains to be accomplished in this arena especially with regard to translating all of this new knowledge to the bedside. To this end, a meeting was convened in Philadelphia, PA, on April 18, 2015 sponsored by the QuadW foundation, Children's Oncology Group and CureSearch for Children's Cancer that brought together sarcoma clinicians and scientists from North America to review the current state of pediatric sarcoma biology and ongoing/planned genomics based clinical trials in an effort to identify and bridge knowledge gaps that continue to exist at present. At the conclusion of the workshop, three key objectives that would significantly further our understanding of sarcoma were identified and a proposal was put forward to develop an all-encompassing pediatric sarcoma biology protocol that would address these specific needs. This review summarizes the proceedings of the workshop.

Original languageEnglish (US)
Pages (from-to)182-194
Number of pages13
JournalCancer genetics
Volume209
Issue number5
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • Genomics
  • Molecular profiling
  • Patient derived xenografts
  • Pediatric sarcoma
  • Precision medicine
  • Sarcoma biology

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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  • Cite this

    Hingorani, P., Janeway, K., Crompton, B. D., Kadoch, C., Mackall, C. L., Khan, J., Shern, J. F., Schiffman, J., Mirabello, L., Savage, S. A., Ladanyi, M., Meltzer, P., Bult, C. J., Adamson, P. C., Lupo, P. J., Mody, R., DuBois, S. G., Parsons, D. W., Khanna, C., ... Reed, D. R. (2016). Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop. Cancer genetics, 209(5), 182-194. https://doi.org/10.1016/j.cancergen.2016.03.004