Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma

Karen K. Lo, Anne O. Rodriguez, Janice Ryu, Vijay P. Khatri

Research output: Contribution to journalArticle

Abstract

Cervical cancer is one of the most common cancers affecting women, with most early disease treated with either surgery or radiation alone with an 85%-95% 5-year survival rate, while locally advanced cervical cancer (LACCA) requires multiple therapeutic modalities. The clear distinction between early and LACCA has, in recent years, blurred as stages IB2 and bulky IIA, which were traditionally thought of as early disease, have been shown to require more treatment than other early stage cervical cancer. LACC is now treated with cisplatin-based chemoradiation therapy based upon the results of the randomized co-operative group studies that demonstrated reduced relative risk of death, local failure rates, and incidence of distant metastases. Recurrent cervical cancer is devastating and is rarely cured. Treatment of recurrent cervical carcinoma depends on the previous therapy, the site of recurrence, and the extent of the recurrence. This review will outline the treatment options for the various stages of cervical cancer.

Original languageEnglish (US)
Pages (from-to)117-128
Number of pages12
JournalOncology Reviews
Volume2
Issue number2
DOIs
StatePublished - Jul 2008

Fingerprint

Uterine Cervical Neoplasms
Carcinoma
Therapeutics
Recurrence
Cisplatin
Survival Rate
Radiation
Neoplasm Metastasis
Incidence
Neoplasms

Keywords

  • Cervical Cancer
  • Chemotherapy
  • Locally Advanced Cancer
  • Lymph Node Staging
  • Radiation
  • Recurrent Disease
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma. / Lo, Karen K.; Rodriguez, Anne O.; Ryu, Janice; Khatri, Vijay P.

In: Oncology Reviews, Vol. 2, No. 2, 07.2008, p. 117-128.

Research output: Contribution to journalArticle

Lo, Karen K. ; Rodriguez, Anne O. ; Ryu, Janice ; Khatri, Vijay P. / Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma. In: Oncology Reviews. 2008 ; Vol. 2, No. 2. pp. 117-128.
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