Current management of purpura fulminans: A multicenter study

Petra M. Warner, R. J. Kagan, K. P. Yakuboff, N. Kemalyan, Tina L Palmieri, David G Greenhalgh, R. L. Sheridan, D. W. Mozingo, D. M. Heimbach, N. S. Gibran, L. Engrav, J. R. Saffle, L. S. Edelman, G. D. Warden

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Seven burn centers performed a 10-yr retrospective chart review of patients diagnosed with purpura fulminans. Patient demographics, etiology, presentation, medical and surgical treatment, and outcome were reviewed. A total of 70 patients were identified. Mean patient age was 13 yr. Neisseria meningitidis was the most common etiologic agent in infants and adolescents whereas Streptococcus commonly afflicted the adult population. Acute management consisted of antibiotic administration, volume resuscitation, ventilatory and inotropic support, with occasional use of corticosteroids (38%) and protein C replacement (9%). Fullthickness skin and soft-tissue necrosis was extensive, requiring skin grafting and amputations in 90% of the patients. One fourth of the patients required amputations of all extremities. Fasciotomies when performed early appeared to limit the level of amputation in 6 of 14 patients. Therefore, fasciotomies during the initial management of these patients may reduce the depth of soft-tissue involvement and the extent of amputations.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalJournal of Burn Care and Rehabilitation
Issue number3
StatePublished - May 2003
Externally publishedYes

ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine


Dive into the research topics of 'Current management of purpura fulminans: A multicenter study'. Together they form a unique fingerprint.

Cite this