Current concepts of analysis of cerebral white matter hyperintensities on magnetic resonance imaging

Mitsuhiro Yoshita, Evan Fletcher, Charles DeCarli

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Cerebrovascular disease is common and associated with cognitive deficits and increased risk for dementia. Until recently, only limited attention has focused on advances in imaging techniques to better define and quantify the spectrum of asymptomatic cerebrovascular disease commonly seen on magnetic resonance imaging, such as abnormal white matter signals. Abnormal signals in cerebral white matter, although nonspecific, are increased in prevalence and severity in association with aging and cerebrovascular risk factors among older individuals. The ubiquitous occurrence of these abnormal white matter signals commonly referred to as white matter hyperintensities (WMHs) and the association with cerebrovascular risk and cognitive impairment among older individuals make scientific evaluation of WMHs an important and much needed avenue of research. In this section, we review current methods of WMH analysis. Strengths and limitation of both quantitative and qualitative methods are discussed initially, followed by a brief review of current magnetic resonance imaging segmentation and mapping techniques that make it possible to assess the anatomical location of WMHs. We conclude by discussing future analytic methods designed to better understand the pathophysiology and cognitive consequences of WMHs.

Original languageEnglish (US)
Pages (from-to)399-407
Number of pages9
JournalTopics in Magnetic Resonance Imaging
Volume16
Issue number6
DOIs
StatePublished - Dec 2005

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Magnetic Resonance Imaging
Cerebrovascular Disorders
Asymptomatic Diseases
White Matter
Dementia
Research

Keywords

  • Brain segmentation
  • Magnetic resonance imaging
  • White matter hyperintensities

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Current concepts of analysis of cerebral white matter hyperintensities on magnetic resonance imaging. / Yoshita, Mitsuhiro; Fletcher, Evan; DeCarli, Charles.

In: Topics in Magnetic Resonance Imaging, Vol. 16, No. 6, 12.2005, p. 399-407.

Research output: Contribution to journalArticle

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