Curcumin Promotes Osteosarcoma Cell Death by Activating miR-125a/ERRα Signal Pathway

Peng Chen, Haibin Wang, Fan Yang, Hongwu Chen, Wei He, Junjian Wang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Curcumin has demonstrated valuable therapeutic potential against a variety of human cancers including osteosarcoma. However, the molecular mechanisms underlying its anti-tumor effect remain to be poorly understood. By RNA sequence profiling, we found that curcumin significantly down-regulates the expression of estrogen-related receptor alpha (ERRα) in osteosarcoma cells. Overexpression of ERRα diminished curcumin-activated apoptotic cell death and scavenged curcumin-induced reactive oxygen species (ROS), while ERRα silencing sensitized osteosarcoma cells to curcumin, resulting in increased inhibition of cell proliferation. In addition, we found that curcumin suppressed the ERRα gene expression through upregulation of miR-125a. Data from this study revealed a novel mechanism for curcumin-mediated apoptotic cell death, which involves tumor cell killing via activating miR-125a/ERRα pathway. Our studies also provide further support for osteosarcoma therapy by targeting ERRα alone or in combination with curcumin.

Original languageEnglish (US)
JournalJournal of Cellular Biochemistry
DOIs
StateAccepted/In press - 2016

Keywords

  • Curcumin
  • Estrogen-related receptor alpha
  • miR-125a
  • Osteosarcoma
  • U2OS cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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