Cumulative sum failure analysis of a policy change from on-pump to off-pump coronary artery bypass grafting

Richard J. Novick, Stephanie A. Fox, Larry W. Stitt, Stuart A. Swinamer, Kris R. Lehnhardt, Reiza Rayman, Walter D Boyd

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background. Use of the sequential probability cumulative sum (CUSUM) technique may be more sensitive than standard statistical analyses in detecting a cluster of surgical failures. We applied CUSUM methods to evaluate the learning curve after a policy change by a single surgeon from routine on-pump (cardiopulmonary bypass [CPB]) to off-pump coronary artery bypass grafting (OPCAB). Methods. Fifty-five consecutive first-time coronary artery bypass patients (CPB group) were compared with the next 55 patients undergoing an attempt at routine OPCAB using the same coronary stabilizer. The goal in OPCAB patients was to obtain complete revascularization, albeit with a low threshold for conversion to CPB to maximize patient safety during the learning curve. Preoperative patient risk was calculated using previously validated models of the Cardiac Care Network of Ontario. The occurrence of operative mortality and nine predefined major complications (myocardial infarction, bleeding, stroke, renal failure, balloon pump use, mediastinitis, respiratory failure, life-threatening arrhythmia, and sepsis) was compared between the CPB and OPCAB groups using Wilcoxon, Fisher exact, and two-tailed t tests, as well as CUSUM methodology. An intention to treat analysis was performed. Results. The CPB and OPCAB groups had similar predicted mortality and length of stays (2.2% ± 2.5%, 8.1 ± 2.5 days versus 2.4% ± 3.5%, 8.1 ± 2.4 days, respectively). The mean number of grafts per patient was 3.1 ± 0.7 in the CPB group versus 3.0 ± 0.7 in the OPCAB group (p = 0.45). Two of 55 (3.6%) CPB patients died, as opposed to 1 of 55 (1.8%) OPCAB patients (p = 0.99). Eight of 55 CPB patients (14.5%) incurred major complications, as opposed to 4 of 55 (7.3%) OPCAB patients (p = 0.36). Median hospital length of stay was 6.0 days in the CPB group versus 5.0 days in the OPCAB group (p = 0.28). On CUSUM analysis, the failure curve in CPB patients approached the upper 80% alert line after eight cases, whereas the curve in OPCAB patients reached below the lower 80% (reassurance) boundary 28 cases after the policy change, indicating superior results in the OPCAB group despite the learning curve. Conclusions. A policy change from coronary artery bypass on CPB to routinely attempting OPCAB can be accomplished safely despite the learning curve. CUSUM analysis was more sensitive than standard statistical methods in detecting a cluster of surgical failures and successes.

Original languageEnglish (US)
JournalAnnals of Thoracic Surgery
Volume72
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

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Off-Pump Coronary Artery Bypass
Policy Making
Coronary Artery Bypass
Cardiopulmonary Bypass
Learning Curve
Length of Stay
Mediastinitis
Intention to Treat Analysis
Mortality
Ontario
Patient Safety
Respiratory Insufficiency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Novick, R. J., Fox, S. A., Stitt, L. W., Swinamer, S. A., Lehnhardt, K. R., Rayman, R., & Boyd, W. D. (2001). Cumulative sum failure analysis of a policy change from on-pump to off-pump coronary artery bypass grafting. Annals of Thoracic Surgery, 72(3). https://doi.org/10.1016/S0003-4975(01)02949-6

Cumulative sum failure analysis of a policy change from on-pump to off-pump coronary artery bypass grafting. / Novick, Richard J.; Fox, Stephanie A.; Stitt, Larry W.; Swinamer, Stuart A.; Lehnhardt, Kris R.; Rayman, Reiza; Boyd, Walter D.

In: Annals of Thoracic Surgery, Vol. 72, No. 3, 2001.

Research output: Contribution to journalArticle

Novick, Richard J. ; Fox, Stephanie A. ; Stitt, Larry W. ; Swinamer, Stuart A. ; Lehnhardt, Kris R. ; Rayman, Reiza ; Boyd, Walter D. / Cumulative sum failure analysis of a policy change from on-pump to off-pump coronary artery bypass grafting. In: Annals of Thoracic Surgery. 2001 ; Vol. 72, No. 3.
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abstract = "Background. Use of the sequential probability cumulative sum (CUSUM) technique may be more sensitive than standard statistical analyses in detecting a cluster of surgical failures. We applied CUSUM methods to evaluate the learning curve after a policy change by a single surgeon from routine on-pump (cardiopulmonary bypass [CPB]) to off-pump coronary artery bypass grafting (OPCAB). Methods. Fifty-five consecutive first-time coronary artery bypass patients (CPB group) were compared with the next 55 patients undergoing an attempt at routine OPCAB using the same coronary stabilizer. The goal in OPCAB patients was to obtain complete revascularization, albeit with a low threshold for conversion to CPB to maximize patient safety during the learning curve. Preoperative patient risk was calculated using previously validated models of the Cardiac Care Network of Ontario. The occurrence of operative mortality and nine predefined major complications (myocardial infarction, bleeding, stroke, renal failure, balloon pump use, mediastinitis, respiratory failure, life-threatening arrhythmia, and sepsis) was compared between the CPB and OPCAB groups using Wilcoxon, Fisher exact, and two-tailed t tests, as well as CUSUM methodology. An intention to treat analysis was performed. Results. The CPB and OPCAB groups had similar predicted mortality and length of stays (2.2{\%} ± 2.5{\%}, 8.1 ± 2.5 days versus 2.4{\%} ± 3.5{\%}, 8.1 ± 2.4 days, respectively). The mean number of grafts per patient was 3.1 ± 0.7 in the CPB group versus 3.0 ± 0.7 in the OPCAB group (p = 0.45). Two of 55 (3.6{\%}) CPB patients died, as opposed to 1 of 55 (1.8{\%}) OPCAB patients (p = 0.99). Eight of 55 CPB patients (14.5{\%}) incurred major complications, as opposed to 4 of 55 (7.3{\%}) OPCAB patients (p = 0.36). Median hospital length of stay was 6.0 days in the CPB group versus 5.0 days in the OPCAB group (p = 0.28). On CUSUM analysis, the failure curve in CPB patients approached the upper 80{\%} alert line after eight cases, whereas the curve in OPCAB patients reached below the lower 80{\%} (reassurance) boundary 28 cases after the policy change, indicating superior results in the OPCAB group despite the learning curve. Conclusions. A policy change from coronary artery bypass on CPB to routinely attempting OPCAB can be accomplished safely despite the learning curve. CUSUM analysis was more sensitive than standard statistical methods in detecting a cluster of surgical failures and successes.",
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T1 - Cumulative sum failure analysis of a policy change from on-pump to off-pump coronary artery bypass grafting

AU - Novick, Richard J.

AU - Fox, Stephanie A.

AU - Stitt, Larry W.

AU - Swinamer, Stuart A.

AU - Lehnhardt, Kris R.

AU - Rayman, Reiza

AU - Boyd, Walter D

PY - 2001

Y1 - 2001

N2 - Background. Use of the sequential probability cumulative sum (CUSUM) technique may be more sensitive than standard statistical analyses in detecting a cluster of surgical failures. We applied CUSUM methods to evaluate the learning curve after a policy change by a single surgeon from routine on-pump (cardiopulmonary bypass [CPB]) to off-pump coronary artery bypass grafting (OPCAB). Methods. Fifty-five consecutive first-time coronary artery bypass patients (CPB group) were compared with the next 55 patients undergoing an attempt at routine OPCAB using the same coronary stabilizer. The goal in OPCAB patients was to obtain complete revascularization, albeit with a low threshold for conversion to CPB to maximize patient safety during the learning curve. Preoperative patient risk was calculated using previously validated models of the Cardiac Care Network of Ontario. The occurrence of operative mortality and nine predefined major complications (myocardial infarction, bleeding, stroke, renal failure, balloon pump use, mediastinitis, respiratory failure, life-threatening arrhythmia, and sepsis) was compared between the CPB and OPCAB groups using Wilcoxon, Fisher exact, and two-tailed t tests, as well as CUSUM methodology. An intention to treat analysis was performed. Results. The CPB and OPCAB groups had similar predicted mortality and length of stays (2.2% ± 2.5%, 8.1 ± 2.5 days versus 2.4% ± 3.5%, 8.1 ± 2.4 days, respectively). The mean number of grafts per patient was 3.1 ± 0.7 in the CPB group versus 3.0 ± 0.7 in the OPCAB group (p = 0.45). Two of 55 (3.6%) CPB patients died, as opposed to 1 of 55 (1.8%) OPCAB patients (p = 0.99). Eight of 55 CPB patients (14.5%) incurred major complications, as opposed to 4 of 55 (7.3%) OPCAB patients (p = 0.36). Median hospital length of stay was 6.0 days in the CPB group versus 5.0 days in the OPCAB group (p = 0.28). On CUSUM analysis, the failure curve in CPB patients approached the upper 80% alert line after eight cases, whereas the curve in OPCAB patients reached below the lower 80% (reassurance) boundary 28 cases after the policy change, indicating superior results in the OPCAB group despite the learning curve. Conclusions. A policy change from coronary artery bypass on CPB to routinely attempting OPCAB can be accomplished safely despite the learning curve. CUSUM analysis was more sensitive than standard statistical methods in detecting a cluster of surgical failures and successes.

AB - Background. Use of the sequential probability cumulative sum (CUSUM) technique may be more sensitive than standard statistical analyses in detecting a cluster of surgical failures. We applied CUSUM methods to evaluate the learning curve after a policy change by a single surgeon from routine on-pump (cardiopulmonary bypass [CPB]) to off-pump coronary artery bypass grafting (OPCAB). Methods. Fifty-five consecutive first-time coronary artery bypass patients (CPB group) were compared with the next 55 patients undergoing an attempt at routine OPCAB using the same coronary stabilizer. The goal in OPCAB patients was to obtain complete revascularization, albeit with a low threshold for conversion to CPB to maximize patient safety during the learning curve. Preoperative patient risk was calculated using previously validated models of the Cardiac Care Network of Ontario. The occurrence of operative mortality and nine predefined major complications (myocardial infarction, bleeding, stroke, renal failure, balloon pump use, mediastinitis, respiratory failure, life-threatening arrhythmia, and sepsis) was compared between the CPB and OPCAB groups using Wilcoxon, Fisher exact, and two-tailed t tests, as well as CUSUM methodology. An intention to treat analysis was performed. Results. The CPB and OPCAB groups had similar predicted mortality and length of stays (2.2% ± 2.5%, 8.1 ± 2.5 days versus 2.4% ± 3.5%, 8.1 ± 2.4 days, respectively). The mean number of grafts per patient was 3.1 ± 0.7 in the CPB group versus 3.0 ± 0.7 in the OPCAB group (p = 0.45). Two of 55 (3.6%) CPB patients died, as opposed to 1 of 55 (1.8%) OPCAB patients (p = 0.99). Eight of 55 CPB patients (14.5%) incurred major complications, as opposed to 4 of 55 (7.3%) OPCAB patients (p = 0.36). Median hospital length of stay was 6.0 days in the CPB group versus 5.0 days in the OPCAB group (p = 0.28). On CUSUM analysis, the failure curve in CPB patients approached the upper 80% alert line after eight cases, whereas the curve in OPCAB patients reached below the lower 80% (reassurance) boundary 28 cases after the policy change, indicating superior results in the OPCAB group despite the learning curve. Conclusions. A policy change from coronary artery bypass on CPB to routinely attempting OPCAB can be accomplished safely despite the learning curve. CUSUM analysis was more sensitive than standard statistical methods in detecting a cluster of surgical failures and successes.

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