CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus

Sei Myoung Han, Hyun Tae Kim, Kun Woo Kim, Kee Ok Jeon, Kyoung Won Seo, Eun Wha Choi, Hwa Young Youn

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: Canine pemphigus foliaceus is an autoimmune antibody-mediated skin disease characterized by acantholysis. The objective of this case report is to present the successful management of steroid refractory pemphigus foliaceus with cytotoxic T-lymphocyte antigen 4 (CTLA4)-overexpressing adipose tissue mesenchymal stem cells (ATMSCs). Case presentation: A 10-year-old, 12.3-kg, castrated male Shih Tzu presented with severe pruritus and anorexia. The diagnosis of pemphigus foliaceus was made based on its history, physical examination, and histopathology results of a skin biopsy. Treatment with prednisolone and combination therapy of other immunosuppressive drugs had failed; therefore, immunosuppressive gene, CTLA4 overexpressing ATMSCs (CTLA4-ATMSCs) and/or naive ATMSCs administration was performed with the consent of the owner. ATMSCs were administered 21 times over a period of 20 months with intervals of 2 to 8 week. Prednisolone was gradually tapered concurrently and no relapse of the clinical signs was observed. After the termination of CTLA4-ATMSCs and/or naive ATMSCs treatment, the skin lesions had improved and could be managed with a low dose of prednisolone for 12 months. Conclusion: CTLA4-ATMSCs or naive ATMSCs transplantation may be beneficial as adjunctive therapy to initiate and maintain the remission of skin lesions caused by pemphigus foliaceus in veterinary medicine.

Original languageEnglish (US)
Article number49
JournalBMC Veterinary Research
Volume11
Issue number1
DOIs
StatePublished - Mar 6 2015
Externally publishedYes

Keywords

  • Autoimmune disease
  • CTLA4
  • Dog
  • Mesenchymal stem cell
  • Pemphigus foliaceus

ASJC Scopus subject areas

  • veterinary(all)

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