CTHRC1 expression in primary biliary cholangitis

Yi Kang Li, Yan Mei Li, You Li, Yi Ran Wei, Jun Zhang, Bo Li, Zheng Rui You, Yong Chen, Bing Yuan Huang, Qi Miao, Qi Xia Wang, Yan Shen Peng, M. Eric Gershwin, Ru Qi Tang, Zhao Lian Bian, Xiong Ma

Research output: Contribution to journalArticle

Abstract

Objectives: Collagen triple helix repeat containing-1 (CTHRC1) is a highly conserved extracellular matrix glycoprotein that is overexpressed in two murine models of cholestatic liver fibrosis. Elevated CTHRC1 has been found to attenuate liver fibrosis in these murine models, thus we aimed to study the expression of CTHRC1 in patients with cholestatic liver diseases and its correlation with hepatic conditions. Methods: Ninety patients with chronic liver disease, including 48 had primary biliary cholangitis (PBC), 18 had primary sclerosing cholangitis (PSC) and 24 had chronic hepatitis B (CHB), together with five healthy controls (HC), were recruited to this study. Participants’ liver sections were analyzed using immunohistochemistry. Serum CTHRC1 levels in another cohort of 59 patients with PBC and 10 age-matched HC were detected by enzyme-linked immunosorbent assay. Results: CTHRC1 protein was primarily expressed in activated hepatic stellate cells (HSC). CTHRC1 expression was significantly increased in the PBC and PSC groups, compared with the HC and CHB groups. Importantly, the hepatic fibrosis stage of the PBC group was positively correlated with hepatic CTHRC1 expression (r = 0.425, P = 0.003). Meanwhile, there were significant correlations between serum CTHRC1 levels and both the degrees of hepatic inflammation and fibrosis stage in the PBC group (r = 0.300, P = 0.022; r = 0.321, P = 0.012). Conclusion: CTHRC1 may play a role in hepatic fibrogenesis in PBC and that serum CTHRC1 may be a potential novel noninvasive biomarker in the assessment of liver fibrosis and inflammation.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalJournal of Digestive Diseases
Volume20
Issue number7
DOIs
StatePublished - Jul 1 2019

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Cholangitis
Collagen
Liver
Liver Cirrhosis
Sclerosing Cholangitis
Chronic Hepatitis B
Liver Diseases
Fibrosis
Serum
Inflammation
Hepatic Stellate Cells
Extracellular Matrix
Glycoproteins
Chronic Disease
Biomarkers
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry

Keywords

  • cholestasis
  • collagen triple helix repeat containing-1
  • fibrosis
  • primary biliary cholangitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Li, Y. K., Li, Y. M., Li, Y., Wei, Y. R., Zhang, J., Li, B., ... Ma, X. (2019). CTHRC1 expression in primary biliary cholangitis. Journal of Digestive Diseases, 20(7), 371-376. https://doi.org/10.1111/1751-2980.12791

CTHRC1 expression in primary biliary cholangitis. / Li, Yi Kang; Li, Yan Mei; Li, You; Wei, Yi Ran; Zhang, Jun; Li, Bo; You, Zheng Rui; Chen, Yong; Huang, Bing Yuan; Miao, Qi; Wang, Qi Xia; Peng, Yan Shen; Gershwin, M. Eric; Tang, Ru Qi; Bian, Zhao Lian; Ma, Xiong.

In: Journal of Digestive Diseases, Vol. 20, No. 7, 01.07.2019, p. 371-376.

Research output: Contribution to journalArticle

Li, YK, Li, YM, Li, Y, Wei, YR, Zhang, J, Li, B, You, ZR, Chen, Y, Huang, BY, Miao, Q, Wang, QX, Peng, YS, Gershwin, ME, Tang, RQ, Bian, ZL & Ma, X 2019, 'CTHRC1 expression in primary biliary cholangitis', Journal of Digestive Diseases, vol. 20, no. 7, pp. 371-376. https://doi.org/10.1111/1751-2980.12791
Li YK, Li YM, Li Y, Wei YR, Zhang J, Li B et al. CTHRC1 expression in primary biliary cholangitis. Journal of Digestive Diseases. 2019 Jul 1;20(7):371-376. https://doi.org/10.1111/1751-2980.12791
Li, Yi Kang ; Li, Yan Mei ; Li, You ; Wei, Yi Ran ; Zhang, Jun ; Li, Bo ; You, Zheng Rui ; Chen, Yong ; Huang, Bing Yuan ; Miao, Qi ; Wang, Qi Xia ; Peng, Yan Shen ; Gershwin, M. Eric ; Tang, Ru Qi ; Bian, Zhao Lian ; Ma, Xiong. / CTHRC1 expression in primary biliary cholangitis. In: Journal of Digestive Diseases. 2019 ; Vol. 20, No. 7. pp. 371-376.
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abstract = "Objectives: Collagen triple helix repeat containing-1 (CTHRC1) is a highly conserved extracellular matrix glycoprotein that is overexpressed in two murine models of cholestatic liver fibrosis. Elevated CTHRC1 has been found to attenuate liver fibrosis in these murine models, thus we aimed to study the expression of CTHRC1 in patients with cholestatic liver diseases and its correlation with hepatic conditions. Methods: Ninety patients with chronic liver disease, including 48 had primary biliary cholangitis (PBC), 18 had primary sclerosing cholangitis (PSC) and 24 had chronic hepatitis B (CHB), together with five healthy controls (HC), were recruited to this study. Participants’ liver sections were analyzed using immunohistochemistry. Serum CTHRC1 levels in another cohort of 59 patients with PBC and 10 age-matched HC were detected by enzyme-linked immunosorbent assay. Results: CTHRC1 protein was primarily expressed in activated hepatic stellate cells (HSC). CTHRC1 expression was significantly increased in the PBC and PSC groups, compared with the HC and CHB groups. Importantly, the hepatic fibrosis stage of the PBC group was positively correlated with hepatic CTHRC1 expression (r = 0.425, P = 0.003). Meanwhile, there were significant correlations between serum CTHRC1 levels and both the degrees of hepatic inflammation and fibrosis stage in the PBC group (r = 0.300, P = 0.022; r = 0.321, P = 0.012). Conclusion: CTHRC1 may play a role in hepatic fibrogenesis in PBC and that serum CTHRC1 may be a potential novel noninvasive biomarker in the assessment of liver fibrosis and inflammation.",
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T1 - CTHRC1 expression in primary biliary cholangitis

AU - Li, Yi Kang

AU - Li, Yan Mei

AU - Li, You

AU - Wei, Yi Ran

AU - Zhang, Jun

AU - Li, Bo

AU - You, Zheng Rui

AU - Chen, Yong

AU - Huang, Bing Yuan

AU - Miao, Qi

AU - Wang, Qi Xia

AU - Peng, Yan Shen

AU - Gershwin, M. Eric

AU - Tang, Ru Qi

AU - Bian, Zhao Lian

AU - Ma, Xiong

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objectives: Collagen triple helix repeat containing-1 (CTHRC1) is a highly conserved extracellular matrix glycoprotein that is overexpressed in two murine models of cholestatic liver fibrosis. Elevated CTHRC1 has been found to attenuate liver fibrosis in these murine models, thus we aimed to study the expression of CTHRC1 in patients with cholestatic liver diseases and its correlation with hepatic conditions. Methods: Ninety patients with chronic liver disease, including 48 had primary biliary cholangitis (PBC), 18 had primary sclerosing cholangitis (PSC) and 24 had chronic hepatitis B (CHB), together with five healthy controls (HC), were recruited to this study. Participants’ liver sections were analyzed using immunohistochemistry. Serum CTHRC1 levels in another cohort of 59 patients with PBC and 10 age-matched HC were detected by enzyme-linked immunosorbent assay. Results: CTHRC1 protein was primarily expressed in activated hepatic stellate cells (HSC). CTHRC1 expression was significantly increased in the PBC and PSC groups, compared with the HC and CHB groups. Importantly, the hepatic fibrosis stage of the PBC group was positively correlated with hepatic CTHRC1 expression (r = 0.425, P = 0.003). Meanwhile, there were significant correlations between serum CTHRC1 levels and both the degrees of hepatic inflammation and fibrosis stage in the PBC group (r = 0.300, P = 0.022; r = 0.321, P = 0.012). Conclusion: CTHRC1 may play a role in hepatic fibrogenesis in PBC and that serum CTHRC1 may be a potential novel noninvasive biomarker in the assessment of liver fibrosis and inflammation.

AB - Objectives: Collagen triple helix repeat containing-1 (CTHRC1) is a highly conserved extracellular matrix glycoprotein that is overexpressed in two murine models of cholestatic liver fibrosis. Elevated CTHRC1 has been found to attenuate liver fibrosis in these murine models, thus we aimed to study the expression of CTHRC1 in patients with cholestatic liver diseases and its correlation with hepatic conditions. Methods: Ninety patients with chronic liver disease, including 48 had primary biliary cholangitis (PBC), 18 had primary sclerosing cholangitis (PSC) and 24 had chronic hepatitis B (CHB), together with five healthy controls (HC), were recruited to this study. Participants’ liver sections were analyzed using immunohistochemistry. Serum CTHRC1 levels in another cohort of 59 patients with PBC and 10 age-matched HC were detected by enzyme-linked immunosorbent assay. Results: CTHRC1 protein was primarily expressed in activated hepatic stellate cells (HSC). CTHRC1 expression was significantly increased in the PBC and PSC groups, compared with the HC and CHB groups. Importantly, the hepatic fibrosis stage of the PBC group was positively correlated with hepatic CTHRC1 expression (r = 0.425, P = 0.003). Meanwhile, there were significant correlations between serum CTHRC1 levels and both the degrees of hepatic inflammation and fibrosis stage in the PBC group (r = 0.300, P = 0.022; r = 0.321, P = 0.012). Conclusion: CTHRC1 may play a role in hepatic fibrogenesis in PBC and that serum CTHRC1 may be a potential novel noninvasive biomarker in the assessment of liver fibrosis and inflammation.

KW - cholestasis

KW - collagen triple helix repeat containing-1

KW - fibrosis

KW - primary biliary cholangitis

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