TY - JOUR
T1 - CT ventilation functional image-based IMRT treatment plans are comparable to SPECT ventilation functional image-based plans
AU - Kida, Satoshi
AU - Bal, Matthieu
AU - Kabus, Sven
AU - Negahdar, Mohammadreza
AU - Shan, Xin
AU - Loo, Billy W.
AU - Keall, Paul J.
AU - Yamamoto, Tokihiro
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Purpose To investigate the hypothesis that CT ventilation functional image-based IMRT plans designed to avoid irradiating highly-functional lung regions are comparable to single-photon emission CT (SPECT) ventilation functional image-based plans. Methods and materials Three IMRT plans were created for eight thoracic cancer patients using: (1) CT ventilation functional images, (2) SPECT ventilation functional images, and (3) anatomic images (no functional images). CT ventilation images were created by deformable image registration of 4D-CT image data sets and quantitative analysis. The resulting plans were analyzed for the relationship between the deviations of CT-functional plan metrics from anatomic plan metrics (ΔCT-anatomic) and those of SPECT-functional plans (ΔSPECT-anatomic), and moreover for agreements of various metrics between the CT-functional and SPECT-functional plans. Results The relationship between ΔCT-anatomic and ΔSPECT-anatomic was strong (e.g., R = 0.94; linear regression slope 0.71). The average differences and 95% limits of agreement between the CT-functional and SPECT-functional plan metrics (except for monitor units) for various structures were mostly less than 1% and 2%, respectively. Conclusions This study demonstrated a reasonable agreement between the CT ventilation functional image-based IMRT plans and SPECT-functional plans, suggesting the potential for CT ventilation imaging to serve as a surrogate for SPECT ventilation in functional image-guided radiotherapy.
AB - Purpose To investigate the hypothesis that CT ventilation functional image-based IMRT plans designed to avoid irradiating highly-functional lung regions are comparable to single-photon emission CT (SPECT) ventilation functional image-based plans. Methods and materials Three IMRT plans were created for eight thoracic cancer patients using: (1) CT ventilation functional images, (2) SPECT ventilation functional images, and (3) anatomic images (no functional images). CT ventilation images were created by deformable image registration of 4D-CT image data sets and quantitative analysis. The resulting plans were analyzed for the relationship between the deviations of CT-functional plan metrics from anatomic plan metrics (ΔCT-anatomic) and those of SPECT-functional plans (ΔSPECT-anatomic), and moreover for agreements of various metrics between the CT-functional and SPECT-functional plans. Results The relationship between ΔCT-anatomic and ΔSPECT-anatomic was strong (e.g., R = 0.94; linear regression slope 0.71). The average differences and 95% limits of agreement between the CT-functional and SPECT-functional plan metrics (except for monitor units) for various structures were mostly less than 1% and 2%, respectively. Conclusions This study demonstrated a reasonable agreement between the CT ventilation functional image-based IMRT plans and SPECT-functional plans, suggesting the potential for CT ventilation imaging to serve as a surrogate for SPECT ventilation in functional image-guided radiotherapy.
KW - 4D-CT
KW - Deformable image registration
KW - Lung cancer
KW - Lung functional imaging
KW - Radiation pneumonitis
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U2 - 10.1016/j.radonc.2016.02.019
DO - 10.1016/j.radonc.2016.02.019
M3 - Article
C2 - 26922488
AN - SCOPUS:84959167948
VL - 118
SP - 521
EP - 527
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
SN - 0167-8140
IS - 3
ER -