CT ventilation functional image-based IMRT treatment plans are comparable to SPECT ventilation functional image-based plans

Satoshi Kida, Matthieu Bal, Sven Kabus, Mohammadreza Negahdar, Xin Shan, Billy W. Loo, Paul J. Keall, Tokihiro Yamamoto

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Purpose To investigate the hypothesis that CT ventilation functional image-based IMRT plans designed to avoid irradiating highly-functional lung regions are comparable to single-photon emission CT (SPECT) ventilation functional image-based plans. Methods and materials Three IMRT plans were created for eight thoracic cancer patients using: (1) CT ventilation functional images, (2) SPECT ventilation functional images, and (3) anatomic images (no functional images). CT ventilation images were created by deformable image registration of 4D-CT image data sets and quantitative analysis. The resulting plans were analyzed for the relationship between the deviations of CT-functional plan metrics from anatomic plan metrics (ΔCT-anatomic) and those of SPECT-functional plans (ΔSPECT-anatomic), and moreover for agreements of various metrics between the CT-functional and SPECT-functional plans. Results The relationship between ΔCT-anatomic and ΔSPECT-anatomic was strong (e.g., R = 0.94; linear regression slope 0.71). The average differences and 95% limits of agreement between the CT-functional and SPECT-functional plan metrics (except for monitor units) for various structures were mostly less than 1% and 2%, respectively. Conclusions This study demonstrated a reasonable agreement between the CT ventilation functional image-based IMRT plans and SPECT-functional plans, suggesting the potential for CT ventilation imaging to serve as a surrogate for SPECT ventilation in functional image-guided radiotherapy.

Original languageEnglish (US)
Pages (from-to)521-527
Number of pages7
JournalRadiotherapy and Oncology
Volume118
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • 4D-CT
  • Deformable image registration
  • Lung cancer
  • Lung functional imaging
  • Radiation pneumonitis

ASJC Scopus subject areas

  • Medicine(all)
  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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