CT-derived indices of canine osteosarcoma-affected antebrachial strength

Tanya C. Garcia, Michele A Steffey, Allison Zwingenberger, Leticia Daniel, Susan M Stover

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To improve the prediction of fractures in dogs with bone tumors of the distal radius by identifying computed tomography (CT) indices that correlate with antebrachial bone strength and fracture location. Study design: Prospective experimental study. Animals: Dogs with antebrachial osteosarcoma (n = 10), and normal cadaver bones (n=9). Methods: Antebrachia were imaged with quantitative CT prior to biomechanical testing to failure. CT indices of structural properties were compared to yield force and maximum force using Pearson correlation tests. Results: Straight beam failure (Fs), axial rigidity, curved beam failure (Fc), and craniocaudal bending moment of inertia (MOICrCd) CT indices most highly correlated (0.77 > R > 0.57) with yield and maximum forces when iOSA-affected and control bones were included in the analysis. Considering only OSA-affected bones, Fs, Fc, and axial rigidity correlated highly (0.85 > R > 0.80) with maximum force. In affected bones, the location of minimum axial rigidity and maximum MOICrCd correlated highly (R > 0.85) with the actual fracture location. Conclusions: CT-derived axial rigidity, Fs, and MOICrCd have strong linear relationships with yield and maximum force. These indices should be further evaluated prospectively in OSA-affected dogs that do, and do not, experience pathologic fracture.

Original languageEnglish (US)
Pages (from-to)549-558
Number of pages10
JournalVeterinary Surgery
Volume46
Issue number4
DOIs
StatePublished - May 1 2017

Fingerprint

osteosarcoma
Osteosarcoma
computed tomography
Canidae
Tomography
bones
Bone and Bones
dogs
Dogs
bone strength
Spontaneous Fractures
bone fractures
radius (bone)
Bone Fractures
Cadaver
Forearm
Research Design
experimental design
testing
Prospective Studies

ASJC Scopus subject areas

  • veterinary(all)

Cite this

CT-derived indices of canine osteosarcoma-affected antebrachial strength. / Garcia, Tanya C.; Steffey, Michele A; Zwingenberger, Allison; Daniel, Leticia; Stover, Susan M.

In: Veterinary Surgery, Vol. 46, No. 4, 01.05.2017, p. 549-558.

Research output: Contribution to journalArticle

@article{9abe07352ada4bc9948fa8fb440e0d48,
title = "CT-derived indices of canine osteosarcoma-affected antebrachial strength",
abstract = "Objective: To improve the prediction of fractures in dogs with bone tumors of the distal radius by identifying computed tomography (CT) indices that correlate with antebrachial bone strength and fracture location. Study design: Prospective experimental study. Animals: Dogs with antebrachial osteosarcoma (n = 10), and normal cadaver bones (n=9). Methods: Antebrachia were imaged with quantitative CT prior to biomechanical testing to failure. CT indices of structural properties were compared to yield force and maximum force using Pearson correlation tests. Results: Straight beam failure (Fs), axial rigidity, curved beam failure (Fc), and craniocaudal bending moment of inertia (MOICrCd) CT indices most highly correlated (0.77 > R > 0.57) with yield and maximum forces when iOSA-affected and control bones were included in the analysis. Considering only OSA-affected bones, Fs, Fc, and axial rigidity correlated highly (0.85 > R > 0.80) with maximum force. In affected bones, the location of minimum axial rigidity and maximum MOICrCd correlated highly (R > 0.85) with the actual fracture location. Conclusions: CT-derived axial rigidity, Fs, and MOICrCd have strong linear relationships with yield and maximum force. These indices should be further evaluated prospectively in OSA-affected dogs that do, and do not, experience pathologic fracture.",
author = "Garcia, {Tanya C.} and Steffey, {Michele A} and Allison Zwingenberger and Leticia Daniel and Stover, {Susan M}",
year = "2017",
month = "5",
day = "1",
doi = "10.1111/vsu.12645",
language = "English (US)",
volume = "46",
pages = "549--558",
journal = "Veterinary Surgery",
issn = "0161-3499",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - CT-derived indices of canine osteosarcoma-affected antebrachial strength

AU - Garcia, Tanya C.

AU - Steffey, Michele A

AU - Zwingenberger, Allison

AU - Daniel, Leticia

AU - Stover, Susan M

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objective: To improve the prediction of fractures in dogs with bone tumors of the distal radius by identifying computed tomography (CT) indices that correlate with antebrachial bone strength and fracture location. Study design: Prospective experimental study. Animals: Dogs with antebrachial osteosarcoma (n = 10), and normal cadaver bones (n=9). Methods: Antebrachia were imaged with quantitative CT prior to biomechanical testing to failure. CT indices of structural properties were compared to yield force and maximum force using Pearson correlation tests. Results: Straight beam failure (Fs), axial rigidity, curved beam failure (Fc), and craniocaudal bending moment of inertia (MOICrCd) CT indices most highly correlated (0.77 > R > 0.57) with yield and maximum forces when iOSA-affected and control bones were included in the analysis. Considering only OSA-affected bones, Fs, Fc, and axial rigidity correlated highly (0.85 > R > 0.80) with maximum force. In affected bones, the location of minimum axial rigidity and maximum MOICrCd correlated highly (R > 0.85) with the actual fracture location. Conclusions: CT-derived axial rigidity, Fs, and MOICrCd have strong linear relationships with yield and maximum force. These indices should be further evaluated prospectively in OSA-affected dogs that do, and do not, experience pathologic fracture.

AB - Objective: To improve the prediction of fractures in dogs with bone tumors of the distal radius by identifying computed tomography (CT) indices that correlate with antebrachial bone strength and fracture location. Study design: Prospective experimental study. Animals: Dogs with antebrachial osteosarcoma (n = 10), and normal cadaver bones (n=9). Methods: Antebrachia were imaged with quantitative CT prior to biomechanical testing to failure. CT indices of structural properties were compared to yield force and maximum force using Pearson correlation tests. Results: Straight beam failure (Fs), axial rigidity, curved beam failure (Fc), and craniocaudal bending moment of inertia (MOICrCd) CT indices most highly correlated (0.77 > R > 0.57) with yield and maximum forces when iOSA-affected and control bones were included in the analysis. Considering only OSA-affected bones, Fs, Fc, and axial rigidity correlated highly (0.85 > R > 0.80) with maximum force. In affected bones, the location of minimum axial rigidity and maximum MOICrCd correlated highly (R > 0.85) with the actual fracture location. Conclusions: CT-derived axial rigidity, Fs, and MOICrCd have strong linear relationships with yield and maximum force. These indices should be further evaluated prospectively in OSA-affected dogs that do, and do not, experience pathologic fracture.

UR - http://www.scopus.com/inward/record.url?scp=85018392635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018392635&partnerID=8YFLogxK

U2 - 10.1111/vsu.12645

DO - 10.1111/vsu.12645

M3 - Article

VL - 46

SP - 549

EP - 558

JO - Veterinary Surgery

JF - Veterinary Surgery

SN - 0161-3499

IS - 4

ER -