CRYPTOCOCCUS NEOFORMANS VAR. GRUBII-ASSOCIATED RENAL AMYLOIDOSIS CAUSING PROTEIN-LOSING NEPHROPATHY in A RED KANGAROO (MACROPUS RUFUS)

Mary Irene Thurber, Jenessa Gjeltema, Matthew Sheley, Ray F. Wack

Research output: Contribution to journalArticle

Abstract

A 10-year-old male castrated red kangaroo (Macropus rufus) presented with mandibular swelling. Examination findings included pitting edema with no dental disease evident on examination or radiographs. The results of blood work were moderate azotemia, hypoalbuminemia, and severely elevated urine protein:creatinine ratio (9.9). Radiographs showed an interstitial pattern of the caudal right lung, and an abdominal ultrasound demonstrated scant effusion. Symptomatic and empirical therapy with antibiotics, anti-inflammatory drugs, and an angiotensin-converting enzyme (ACE) inhibitor did not resolve clinical signs. Due to poor prognosis and declining quality of life, euthanasia was elected. Necropsy revealed chronic granulomatous pneumonia of the caudal right lung lobe with intralesional Cryptococcus, identified as C. neoformans var. grubii by DNA sequencing. Severe bilateral glomerular and tubulointerstitial amyloidosis induced protein-losing nephropathy, leading to tri-cavitary effusion, subcutaneous edema, and cachexia. The authors speculate that renal amyloidosis was associated with chronic cryptococcal pneumonia in this red kangaroo.

Original languageEnglish (US)
Pages (from-to)929-932
Number of pages4
JournalJournal of Zoo and Wildlife Medicine
Volume48
Issue number3
DOIs
StatePublished - Sep 1 2017

Fingerprint

Macropus rufus
Macropodidae
amyloidosis
Cryptococcus neoformans
Amyloidosis
kidney diseases
edema
pneumonia
lungs
kidneys
Cryptococcus (Tremellomycetes)
Kidney
anti-inflammatory agents
cachexia
uremia
Edema
Pneumonia
euthanasia
quality of life
creatinine

Keywords

  • Cryptococcus neoformans var. grubii
  • Macropod
  • Protein-losing nephropathy
  • Red kangaroo (Macropus rufus)
  • Renal amyloidosis

ASJC Scopus subject areas

  • Medicine(all)
  • Animal Science and Zoology
  • veterinary(all)

Cite this

CRYPTOCOCCUS NEOFORMANS VAR. GRUBII-ASSOCIATED RENAL AMYLOIDOSIS CAUSING PROTEIN-LOSING NEPHROPATHY in A RED KANGAROO (MACROPUS RUFUS). / Thurber, Mary Irene; Gjeltema, Jenessa; Sheley, Matthew; Wack, Ray F.

In: Journal of Zoo and Wildlife Medicine, Vol. 48, No. 3, 01.09.2017, p. 929-932.

Research output: Contribution to journalArticle

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abstract = "A 10-year-old male castrated red kangaroo (Macropus rufus) presented with mandibular swelling. Examination findings included pitting edema with no dental disease evident on examination or radiographs. The results of blood work were moderate azotemia, hypoalbuminemia, and severely elevated urine protein:creatinine ratio (9.9). Radiographs showed an interstitial pattern of the caudal right lung, and an abdominal ultrasound demonstrated scant effusion. Symptomatic and empirical therapy with antibiotics, anti-inflammatory drugs, and an angiotensin-converting enzyme (ACE) inhibitor did not resolve clinical signs. Due to poor prognosis and declining quality of life, euthanasia was elected. Necropsy revealed chronic granulomatous pneumonia of the caudal right lung lobe with intralesional Cryptococcus, identified as C. neoformans var. grubii by DNA sequencing. Severe bilateral glomerular and tubulointerstitial amyloidosis induced protein-losing nephropathy, leading to tri-cavitary effusion, subcutaneous edema, and cachexia. The authors speculate that renal amyloidosis was associated with chronic cryptococcal pneumonia in this red kangaroo.",
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