Abstract
DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. BecauseDNAmethylation is reversible, there ismuchinterest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and distal regulatory elements. Additional in vivo genome-wide characterization of transcription factor binding patterns and high-resolution DNA methylation analyses are clearly required for stronger support of each model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 34287-34294 |
| Number of pages | 8 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 48 |
| DOIs | |
| State | Published - Nov 29 2013 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Cross-talk between site-specific transcription factors and DNA methylation states. / Blattler, Adam; Farnham, Peggy J.
In: Journal of Biological Chemistry, Vol. 288, No. 48, 29.11.2013, p. 34287-34294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cross-talk between site-specific transcription factors and DNA methylation states
AU - Blattler, Adam
AU - Farnham, Peggy J.
PY - 2013/11/29
Y1 - 2013/11/29
N2 - DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. BecauseDNAmethylation is reversible, there ismuchinterest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and distal regulatory elements. Additional in vivo genome-wide characterization of transcription factor binding patterns and high-resolution DNA methylation analyses are clearly required for stronger support of each model.
AB - DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. BecauseDNAmethylation is reversible, there ismuchinterest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and distal regulatory elements. Additional in vivo genome-wide characterization of transcription factor binding patterns and high-resolution DNA methylation analyses are clearly required for stronger support of each model.
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UR - http://www.scopus.com/inward/citedby.url?scp=84888994574&partnerID=8YFLogxK
U2 - 10.1074/jbc.R113.512517
DO - 10.1074/jbc.R113.512517
M3 - Article
VL - 288
SP - 34287
EP - 34294
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 48
ER -