Cross-talk between site-specific transcription factors and DNA methylation states

Adam Blattler, Peggy J. Farnham

Research output: Contribution to journalArticlepeer-review

124 Scopus citations


DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. BecauseDNAmethylation is reversible, there ismuchinterest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and distal regulatory elements. Additional in vivo genome-wide characterization of transcription factor binding patterns and high-resolution DNA methylation analyses are clearly required for stronger support of each model.

Original languageEnglish (US)
Pages (from-to)34287-34294
Number of pages8
JournalJournal of Biological Chemistry
Issue number48
StatePublished - Nov 29 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology


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