Abstract
DNA methylation, which occurs predominantly at CpG dinucleotides, is a potent epigenetic repressor of transcription. BecauseDNAmethylation is reversible, there ismuchinterest in understanding the mechanisms by which it can be regulated by DNA-binding transcription factors. We discuss several models that, by incorporating sequence motifs, CpG density, and methylation levels, attempt to link the binding of a transcription factor with the acquisition or loss of DNA methylation at promoters and distal regulatory elements. Additional in vivo genome-wide characterization of transcription factor binding patterns and high-resolution DNA methylation analyses are clearly required for stronger support of each model.
Original language | English (US) |
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Pages (from-to) | 34287-34294 |
Number of pages | 8 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 48 |
DOIs | |
State | Published - Nov 29 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology