Critical periods for experience-dependent synaptic scaling in visual cortex

Niraj S. Desai, Robert H. Cudmore, Sacha B. Nelson, Gina G. Turrigiano

Research output: Contribution to journalArticle

391 Citations (Scopus)

Abstract

The mechanisms underlying experience-dependent plasticity and refinement of central circuits are not yet fully understood. A non-Hebbian form of synaptic plasticity, which scales synaptic strengths up or down to stabilize firing rates, has recently been discovered in cultured neuronal networks. Here we demonstrate the existence of a similar mechanism in the intact rodent visual cortex. The frequency of miniature excitatory postsynaptic currents (mEPSCs) in principal neurons increased steeply between post-natal days 12 and 23. There was a concomitant decrease in mEPSC amplitude, which was prevented by rearing rats in complete darkness from 12 days of age. In addition, as little as two days of monocular deprivation scaled up mEPSC amplitude in a layer- and age-dependent manner. These data indicate that mEPSC amplitudes can be globally scaled up or down as a function of development and sensory experience, and suggest that synaptic scaling may be involved in the activity-dependent refinement of cortical connectivity.

Original languageEnglish (US)
Pages (from-to)783-789
Number of pages7
JournalNature Neuroscience
Volume5
Issue number8
DOIs
StatePublished - Aug 10 2002
Externally publishedYes

Fingerprint

Excitatory Postsynaptic Potentials
Visual Cortex
Neuronal Plasticity
Darkness
Rodentia
Neurons
Critical Period (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Critical periods for experience-dependent synaptic scaling in visual cortex. / Desai, Niraj S.; Cudmore, Robert H.; Nelson, Sacha B.; Turrigiano, Gina G.

In: Nature Neuroscience, Vol. 5, No. 8, 10.08.2002, p. 783-789.

Research output: Contribution to journalArticle

Desai, Niraj S. ; Cudmore, Robert H. ; Nelson, Sacha B. ; Turrigiano, Gina G. / Critical periods for experience-dependent synaptic scaling in visual cortex. In: Nature Neuroscience. 2002 ; Vol. 5, No. 8. pp. 783-789.
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