Critical overview of mitochondrial nitric-oxide synthase

Kazunobu Kato, Cecilia R Giulivi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The recent discovery of mitochondrial nitric-oxide synthase (mtNOS) has provided novel information on mitochondrial biology. mtNOS, localized at the inner membrane, functions as one of the important regulatory factors that affect cellular respiration in mitochondria. The distribution of mtNOS in diverse organs of many species suggests its biological importance. Changes in mtNOS expression and activity in many pathophysiological situations may imply its significant involvement in various NO-related biological phenomena. The functional coordination of mtNOS with other NOSs present in the same or adjacent tissues is unknown as it is most of the regulatory mechanisms of mtNOS expression. Thus, future studies will be required to validate the physiological significance of mtNOS, and to elucidate its regulatory mechanisms on cellular energy metabolism in mitochondria.

Original languageEnglish (US)
Pages (from-to)2725-2738
Number of pages14
JournalFrontiers in Bioscience
Volume11
Issue numberSUPPL. 2
DOIs
StatePublished - 2006

Fingerprint

Nitric Oxide Synthase
Mitochondria
Cell Respiration
Biological Phenomena
Energy Metabolism
Tissue
Membranes

Keywords

  • Apoptosis
  • Calcium Signaling
  • Cellular Respiration
  • Mitochondria
  • Mitochondrial Nitric Oxide
  • Mitochondrion
  • mtNOS
  • Peroxynitrite
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Critical overview of mitochondrial nitric-oxide synthase. / Kato, Kazunobu; Giulivi, Cecilia R.

In: Frontiers in Bioscience, Vol. 11, No. SUPPL. 2, 2006, p. 2725-2738.

Research output: Contribution to journalArticle

Kato, Kazunobu ; Giulivi, Cecilia R. / Critical overview of mitochondrial nitric-oxide synthase. In: Frontiers in Bioscience. 2006 ; Vol. 11, No. SUPPL. 2. pp. 2725-2738.
@article{5b4a8e4b92b746a9acb5ed8588638164,
title = "Critical overview of mitochondrial nitric-oxide synthase",
abstract = "The recent discovery of mitochondrial nitric-oxide synthase (mtNOS) has provided novel information on mitochondrial biology. mtNOS, localized at the inner membrane, functions as one of the important regulatory factors that affect cellular respiration in mitochondria. The distribution of mtNOS in diverse organs of many species suggests its biological importance. Changes in mtNOS expression and activity in many pathophysiological situations may imply its significant involvement in various NO-related biological phenomena. The functional coordination of mtNOS with other NOSs present in the same or adjacent tissues is unknown as it is most of the regulatory mechanisms of mtNOS expression. Thus, future studies will be required to validate the physiological significance of mtNOS, and to elucidate its regulatory mechanisms on cellular energy metabolism in mitochondria.",
keywords = "Apoptosis, Calcium Signaling, Cellular Respiration, Mitochondria, Mitochondrial Nitric Oxide, Mitochondrion, mtNOS, Peroxynitrite, Review",
author = "Kazunobu Kato and Giulivi, {Cecilia R}",
year = "2006",
doi = "10.2741/2002",
language = "English (US)",
volume = "11",
pages = "2725--2738",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Critical overview of mitochondrial nitric-oxide synthase

AU - Kato, Kazunobu

AU - Giulivi, Cecilia R

PY - 2006

Y1 - 2006

N2 - The recent discovery of mitochondrial nitric-oxide synthase (mtNOS) has provided novel information on mitochondrial biology. mtNOS, localized at the inner membrane, functions as one of the important regulatory factors that affect cellular respiration in mitochondria. The distribution of mtNOS in diverse organs of many species suggests its biological importance. Changes in mtNOS expression and activity in many pathophysiological situations may imply its significant involvement in various NO-related biological phenomena. The functional coordination of mtNOS with other NOSs present in the same or adjacent tissues is unknown as it is most of the regulatory mechanisms of mtNOS expression. Thus, future studies will be required to validate the physiological significance of mtNOS, and to elucidate its regulatory mechanisms on cellular energy metabolism in mitochondria.

AB - The recent discovery of mitochondrial nitric-oxide synthase (mtNOS) has provided novel information on mitochondrial biology. mtNOS, localized at the inner membrane, functions as one of the important regulatory factors that affect cellular respiration in mitochondria. The distribution of mtNOS in diverse organs of many species suggests its biological importance. Changes in mtNOS expression and activity in many pathophysiological situations may imply its significant involvement in various NO-related biological phenomena. The functional coordination of mtNOS with other NOSs present in the same or adjacent tissues is unknown as it is most of the regulatory mechanisms of mtNOS expression. Thus, future studies will be required to validate the physiological significance of mtNOS, and to elucidate its regulatory mechanisms on cellular energy metabolism in mitochondria.

KW - Apoptosis

KW - Calcium Signaling

KW - Cellular Respiration

KW - Mitochondria

KW - Mitochondrial Nitric Oxide

KW - Mitochondrion

KW - mtNOS

KW - Peroxynitrite

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=33744494822&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744494822&partnerID=8YFLogxK

U2 - 10.2741/2002

DO - 10.2741/2002

M3 - Article

C2 - 16720345

AN - SCOPUS:33744494822

VL - 11

SP - 2725

EP - 2738

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

IS - SUPPL. 2

ER -