Criteria for validating mouse models of psychiatric diseases

Kathryn K. Chadman, Mu Yang, Jacqueline Crawley

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Animal models of human diseases are in widespread use for biomedical research. Mouse models with a mutation in a single gene or multiple genes are excellent research tools for understanding the role of a specific gene in the etiology of a human genetic disease. Ideally, the mouse phenotypes will recapitulate the human phenotypes exactly. However, exact matches are rare, particularly in mouse models of neuropsychiatric disorders. This article summarizes the current strategies for optimizing the validity of a mouse model of a human brain dysfunction. We address the common question raised by molecular geneticists and clinical researchers in psychiatry, "what is a 'good enough' mouse model"?

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume150
Issue number1
DOIs
StatePublished - Jan 5 2009
Externally publishedYes

Keywords

  • Behavior
  • Model
  • Mouse
  • Phenotyping

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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