CREB at the crossroads of activity-dependent regulation of nervous system development and function

Yesser H. Belgacem, Laura N Borodinsky

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

The central nervous system is a highly plastic network of cells that constantly adjusts its functions to environmental stimuli throughout life. Transcription-dependent mechanisms modify neuronal properties to respond to external stimuli regulating numerous developmental functions, such as cell survival and differentiation, and physiological functions such as learning, memory, and circadian rhythmicity. The discovery and cloning of the cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB) constituted a big step toward deciphering the molecular mechanisms underlying neuronal plasticity. CREB was first discovered in learning and memory studies as a crucial mediator of activity-dependent changes in target gene expression that in turn impose long-lasting modifications of the structure and function of neurons. In this chapter, we review the molecular and signaling mechanisms of neural activity-dependent recruitment of CREB and its cofactors. We discuss the crosstalk between signaling pathways that imprints diverse spatiotemporal patterns of CREB activation allowing for the integration of a wide variety of stimuli.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages19-39
Number of pages21
Volume1015
DOIs
StatePublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1015
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Neurology
Nervous System
Carrier Proteins
Learning
Personnel Selection
Data storage equipment
Neuronal Plasticity
Cloning
Periodicity
Transcription
Crosstalk
Gene expression
Cyclic AMP
Plastics
Neurons
Plasticity
Organism Cloning
Cell Differentiation
Cell Survival
Central Nervous System

Keywords

  • Activity-dependent transcription factors
  • CREB cofactors
  • Crosstalk
  • Plasticity
  • Spatiotemporal integration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Belgacem, Y. H., & Borodinsky, L. N. (2017). CREB at the crossroads of activity-dependent regulation of nervous system development and function. In Advances in Experimental Medicine and Biology (Vol. 1015, pp. 19-39). (Advances in Experimental Medicine and Biology; Vol. 1015). Springer New York LLC. https://doi.org/10.1007/978-3-319-62817-2_2

CREB at the crossroads of activity-dependent regulation of nervous system development and function. / Belgacem, Yesser H.; Borodinsky, Laura N.

Advances in Experimental Medicine and Biology. Vol. 1015 Springer New York LLC, 2017. p. 19-39 (Advances in Experimental Medicine and Biology; Vol. 1015).

Research output: Chapter in Book/Report/Conference proceedingChapter

Belgacem, YH & Borodinsky, LN 2017, CREB at the crossroads of activity-dependent regulation of nervous system development and function. in Advances in Experimental Medicine and Biology. vol. 1015, Advances in Experimental Medicine and Biology, vol. 1015, Springer New York LLC, pp. 19-39. https://doi.org/10.1007/978-3-319-62817-2_2
Belgacem YH, Borodinsky LN. CREB at the crossroads of activity-dependent regulation of nervous system development and function. In Advances in Experimental Medicine and Biology. Vol. 1015. Springer New York LLC. 2017. p. 19-39. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-62817-2_2
Belgacem, Yesser H. ; Borodinsky, Laura N. / CREB at the crossroads of activity-dependent regulation of nervous system development and function. Advances in Experimental Medicine and Biology. Vol. 1015 Springer New York LLC, 2017. pp. 19-39 (Advances in Experimental Medicine and Biology).
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