Creation of an NCI comparative brain tumor consortium: Informing the translation of new knowledge from canine to human brain tumor patients

Amy K. Leblanc, Christina Mazcko, Diane E. Brown, Jennifer W. Koehler, Andrew D. Miller, C. Ryan Miller, R. Timothy Bentley, Rebecca A. Packer, Matthew Breen, C. Elizabeth Boudreau, Jonathan M. Levine, R. Mark Simpson, Charles Halsey, William Kisseberth, John H. Rossmeisl, Peter J Dickinson, Timothy M. Fan, Kara Corps, Kenneth Aldape, Vinay PuduvalliG. Elizabeth Pluhar, Mark R. Gilbert

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

On September 14-15, 2015, a meeting of clinicians and investigators in the fields of veterinary and human neuro-oncology, clinical trials, neuropathology, and drug development was convened at the National Institutes of Health campus in Bethesda, Maryland. This meeting served as the inaugural event launching a new consortium focused on improving the knowledge, development of, and access to naturally occurring canine brain cancer, specifically glioma, as a model for human disease. Within the meeting, a SWOT (strengths, weaknesses, opportunities, and threats) assessment was undertaken to critically evaluate the role that naturally occurring canine brain tumors could have in advancing this aspect of comparative oncology aimed at improving outcomes for dogs and human beings. A summary of this meeting and subsequent discussion are provided to inform the scientific and clinical community of the potential for this initiative. Canine and human comparisons represent an unprecedented opportunity to complement conventional brain tumor research paradigms, addressing a devastating disease for which innovative diagnostic and treatment strategies are clearly needed.

Original languageEnglish (US)
Pages (from-to)1209-1218
Number of pages10
JournalNeuro-Oncology
Volume18
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • comparative oncology
  • glioma
  • translational research

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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