Coupling gating with ion permeation in ClC channels.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In ClC chloride (Cl(-)) channels, unlike cation-selective ion channels, ion permeation is intimately coupled to fast gating. Recent research comparing the crystallographic structure of a bacterial ClC channel with functional studies of a Torpedo ClC channel suggests that gating depends on the negatively charged carboxyl group on a glutamate residue, which blocks the channel pore. In this model, the permeating Cl(-) competes with the carboxyl group for an anion-binding site in the channel pore. This model of Cl(-) competition with a glutamate gate helps explain the effect of intracellular Cl(-) on channel gating; the mechanism underlying the effects of extracellular Cl(-), however, remains to be determined, as does the nature of the Cl(-) channel slow gate.

Original languageEnglish (US)
JournalScience's STKE : signal transduction knowledge environment
Volume2003
Issue number188
StatePublished - 2003

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Chloride Channels
Permeation
Chlorides
Ions
Glutamic Acid
Bacterial Structures
Torpedo
Ion Channels
Anions
Cations
Binding Sites
Research

Cite this

Coupling gating with ion permeation in ClC channels. / Chen, Tsung-Yu.

In: Science's STKE : signal transduction knowledge environment, Vol. 2003, No. 188, 2003.

Research output: Contribution to journalArticle

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