Coupled dynamics of voltage and calcium in paced cardiac cells

Yohannes Shiferaw, Daisuke Sato, Alain Karma

Research output: Contribution to journalArticlepeer-review

132 Scopus citations


We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasi-periodic oscillations of voltage and calcium.

Original languageEnglish (US)
Article number021903
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Issue number2
StatePublished - Feb 2005
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Mathematical Physics
  • Medicine(all)


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