Coupled dynamics of voltage and calcium in paced cardiac cells

Yohannes Shiferaw, Daisuke Sato, Alain Karma

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasi-periodic oscillations of voltage and calcium.

Original languageEnglish (US)
Article number021903
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume71
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

Fingerprint

Calcium Signaling
Calcium
Cardiac
calcium
Voltage
Physiological Model
Cell
Cycling
electric potential
cells
Oscillation
Three-dimensional
oscillations
cycles
Framework

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Mathematical Physics
  • Medicine(all)

Cite this

Coupled dynamics of voltage and calcium in paced cardiac cells. / Shiferaw, Yohannes; Sato, Daisuke; Karma, Alain.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 71, No. 2, 021903, 02.2005.

Research output: Contribution to journalArticle

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