Counting constituents in molecular complexes by fluorescence photon antibunching

Samantha Fore, Thomas R Huser

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Modern single molecule fluorescence microscopy offers new, highly quantitative ways for studying the systems biology of cells while keeping the cells healthy and alive in their natural environment. In this context, a quantum optical technique, photon antibunching, has found a small niche in the continuously growing applications of single molecule techniques to characterize small molecular complexes. Here, we review some of the most recent applications of photon antibunching in biophotonics research, and we provide a guide for how to conduct photon antibunching experiments at the single molecule level by applying techniques borrowed from time-correlated single photon counting (TCSPC). We provide a number of new examples for applications of photon antibunching to the study of multichromophoric molecules and small molecular complexes.

Original languageEnglish (US)
Pages (from-to)996-1005
Number of pages10
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number4
StatePublished - 2007


  • Hanbury-Brown and Twiss
  • molecular complexes
  • photon antibunching
  • single molecule fluorescence
  • time-correlated single photon counting (TCSPC)

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


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