Cost of Stem Cell-Based Tissue-Engineered Airway Transplants in the United Kingdom: Case Series

Emily J. Culme-Seymour, Katrina Mason, Laura Vallejo-Torres, Carla Carvalho, Leanne Partington, Claire Crowley, Nick J. Hamilton, Ed C. Toll, Colin R. Butler, Martin J. Elliott, Martin A. Birchall, Mark W. Lowdell, Chris Mason

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Stem cell-based tissue-engineered tracheas are at an early stage in their product development cycle. Tens of patients have been treated worldwide in predominantly compassionate use settings, demonstrating significant promise. This potentially life-saving treatment is complex, and the cost and its implications for such treatments are yet to be fully understood. The costs are compounded by varying strategies for graft preparation and transplant, resulting in differing clinical and laboratory costs from different research groups. In this study, we present a detailed breakdown of the clinical and manufacturing costs for three of the United Kingdom (UK) patients treated with such transplants. All three patients were treated under Compassionate Use legislation, within the UK National Health Service (NHS) hospital setting. The total costs for the three UK patients treated ranged from $174,420 to $740,500. All three patients were in a state of poor health at time of treatment and had a number of complexities in addition to the restricted airway. This is the first time a cost analysis has been made for a tissue-engineered organ and provides a benchmark for future studies, as well as comparative data for use in reimbursement considerations.

Original languageEnglish (US)
Pages (from-to)208-213
Number of pages6
JournalTissue Engineering - Part A
Issue number3-4
StatePublished - Feb 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Biomaterials


Dive into the research topics of 'Cost of Stem Cell-Based Tissue-Engineered Airway Transplants in the United Kingdom: Case Series'. Together they form a unique fingerprint.

Cite this