Cost-effectiveness of varenicline and three different behavioral treatment formats for smoking cessation

Harold S. Javitz, Susan M. Zbikowski, Mona Deprey, Timothy A. McAfee, Jennifer B. McClure, Julie Richards, Sheryl L Catz, Lisa M. Jack, Gary E. Swan

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

There is a lack of evidence of the relative cost-effectiveness of proactive telephone counseling (PTC) and Web-based delivery of smoking cessation services in conjunction with pharmacotherapy. We calculated the differential cost-effectiveness of three behavioral smoking cessation modalities with varenicline treatment in a randomized trial of current smokers from a large health system. Eligible participants were randomized to one of three smoking cessation interventions: Web-based counseling (n = 401), PTC (n = 402), or combined PTC-Web counseling (n = 399). All participants received a standard 12-week course of varenicline. The primary outcome was a 7-day point prevalent nonsmoking at the 6 month follow-up. The Web intervention was the least expensive followed by the PTC and PTC-Web groups. Costs per additional 6-month nonsmoker and per additional lifetime quitter were $1,278 and $2,601 for Web, $1,472 and $2,995 for PTC, and $1,617 and $3,291 for PTC-Web. Cost per life-year (LY) and quality-adjusted life-year (QALY) saved were $1,148 and $1,136 for Web, $1,320 and $1,308 for PTC, and $1,450 and $1,437 for PTC-Web. Based on the cost per LY and QALY saved, these interventions are among the most cost-effective life-saving medical treatments. Web, PTC, and combined PTC-Web treatments were all highly cost-effective, with the Web treatment being marginally more cost-effective than the PTC or combined PTC-Web treatments.

Original languageEnglish (US)
Pages (from-to)182-190
Number of pages9
JournalTranslational Behavioral Medicine
Volume1
Issue number1
DOIs
StatePublished - Mar 2011
Externally publishedYes

Keywords

  • Behavioral intervention
  • Cost-effectiveness
  • Quality-adjusted life-years saved
  • Smoking cessation
  • Varenicline

ASJC Scopus subject areas

  • Applied Psychology
  • Behavioral Neuroscience

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  • Cite this

    Javitz, H. S., Zbikowski, S. M., Deprey, M., McAfee, T. A., McClure, J. B., Richards, J., Catz, S. L., Jack, L. M., & Swan, G. E. (2011). Cost-effectiveness of varenicline and three different behavioral treatment formats for smoking cessation. Translational Behavioral Medicine, 1(1), 182-190. https://doi.org/10.1007/s13142-010-0009-8