Cortisol stimulation by recombinant interferon-α2

Joe Roosth; Richard B Pollard; S. Lori Brown; Walter J. Meyer

doi:10.1016/0165-5728(86)90037-8

Cortisol stimulation by recombinant interferon-α₂

Joe Roosth, Richard B Pollard, S. Lori Brown, Walter J. Meyer

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α₂. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α₂. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 10⁶ units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

Original language	English (US)
Pages (from-to)	311-316
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/0165-5728(86)90037-8
State	Published - 1986
Externally published	Yes

Keywords

Cortisol stimulation
Interferon-α
recombinant
Serum
Tumor

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Clinical Neurology
Neurology

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10.1016/0165-5728(86)90037-8

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AU - Roosth, Joe

AU - Pollard, Richard B

AU - Brown, S. Lori

AU - Meyer, Walter J.

PY - 1986

Y1 - 1986

N2 - Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

AB - Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

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KW - Interferon-α

KW - recombinant

KW - Serum

KW - Tumor

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