Abstract
Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 311-316 |
| Number of pages | 6 |
| Journal | Journal of Neuroimmunology |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |
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Keywords
- Cortisol stimulation
- Interferon-α
- recombinant
- Serum
- Tumor
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology
Cite this
Cortisol stimulation by recombinant interferon-α2 . / Roosth, Joe; Pollard, Richard B; Brown, S. Lori; Meyer, Walter J.
In: Journal of Neuroimmunology, Vol. 12, No. 4, 1986, p. 311-316.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cortisol stimulation by recombinant interferon-α2
AU - Roosth, Joe
AU - Pollard, Richard B
AU - Brown, S. Lori
AU - Meyer, Walter J.
PY - 1986
Y1 - 1986
N2 - Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.
AB - Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.
KW - Cortisol stimulation
KW - Interferon-α
KW - recombinant
KW - Serum
KW - Tumor
UR - http://www.scopus.com/inward/record.url?scp=0022522878&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022522878&partnerID=8YFLogxK
U2 - 10.1016/0165-5728(86)90037-8
DO - 10.1016/0165-5728(86)90037-8
M3 - Article
C2 - 3760157
AN - SCOPUS:0022522878
VL - 12
SP - 311
EP - 316
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 4
ER -