Cortisol stimulation by recombinant interferon-α2

Joe Roosth, Richard B Pollard, S. Lori Brown, Walter J. Meyer

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-α2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-α2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 × 106 units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalJournal of Neuroimmunology
Volume12
Issue number4
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • Cortisol stimulation
  • Interferon-α
  • recombinant
  • Serum
  • Tumor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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