Corticotropin releasing hormone (CRH) and urocortins are key central and peripheral regulators of stress, anxiety, energy balance and metabolism

M. R. DiGruccio, M. O. Huising

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Corticotropin releasing factor (CRF) initiates a cascade of endocrine events collectively known as the neuroendocrine stress response. The CRF neuropeptide family includes the urocortins (Ucn1, Ucn2, and Ucn3). These neuropeptides signal via two CRF receptors and are subjected to the modulatory actions of several soluble binding-proteins. While CRF and urocortins are often associated with control of the stress response, they are also involved in arousal, anxiety, depression, feeding behavior, cardiovascular activity, pregnancy, and plasma glucose homeostasis.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Pages231-237
Number of pages7
ISBN (Electronic)9780128093245
DOIs
StatePublished - Jan 1 2016

Keywords

  • Anxiety
  • Arousal
  • Cardiovascular system
  • CRF
  • CRF-BP
  • CRFR1
  • CRFR2
  • Depression
  • Diabetes
  • Feeding
  • Neuropeptide
  • Pancreas
  • Pregnancy
  • Sauvagine
  • Stress
  • Urocortin-2
  • Urocortin-3
  • Urotensin

ASJC Scopus subject areas

  • Medicine(all)

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