Corticotropin releasing hormone (CRH) and urocortins are key central and peripheral regulators of stress, anxiety, energy balance and metabolism

M. R. DiGruccio; M. O. Huising

doi:10.1016/B978-0-12-809324-5.02214-8

Corticotropin releasing hormone (CRH) and urocortins are key central and peripheral regulators of stress, anxiety, energy balance and metabolism

M. R. DiGruccio, M. O. Huising

Physiology and Membrane Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Corticotropin releasing factor (CRF) initiates a cascade of endocrine events collectively known as the neuroendocrine stress response. The CRF neuropeptide family includes the urocortins (Ucn1, Ucn2, and Ucn3). These neuropeptides signal via two CRF receptors and are subjected to the modulatory actions of several soluble binding-proteins. While CRF and urocortins are often associated with control of the stress response, they are also involved in arousal, anxiety, depression, feeding behavior, cardiovascular activity, pregnancy, and plasma glucose homeostasis.

Original language	English (US)
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier Science Ltd.
Pages	231-237
Number of pages	7
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.02214-8
State	Published - Jan 1 2016

Keywords

Anxiety
Arousal
Cardiovascular system
CRF
CRF-BP
CRFR1
CRFR2
Depression
Diabetes
Feeding
Neuropeptide
Pancreas
Pregnancy
Sauvagine
Stress
Urocortin-2
Urocortin-3
Urotensin

ASJC Scopus subject areas

Medicine(all)

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Corticotropin releasing hormone (CRH) and urocortins are key central and peripheral regulators of stress, anxiety, energy balance and metabolism. / DiGruccio, M. R.; Huising, M. O.

The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. Elsevier Science Ltd., 2016. p. 231-237.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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abstract = "Corticotropin releasing factor (CRF) initiates a cascade of endocrine events collectively known as the neuroendocrine stress response. The CRF neuropeptide family includes the urocortins (Ucn1, Ucn2, and Ucn3). These neuropeptides signal via two CRF receptors and are subjected to the modulatory actions of several soluble binding-proteins. While CRF and urocortins are often associated with control of the stress response, they are also involved in arousal, anxiety, depression, feeding behavior, cardiovascular activity, pregnancy, and plasma glucose homeostasis.",

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KW - Arousal

KW - Cardiovascular system

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KW - CRF-BP

KW - CRFR1

KW - CRFR2

KW - Depression

KW - Diabetes

KW - Feeding

KW - Neuropeptide

KW - Pancreas

KW - Pregnancy

KW - Sauvagine

KW - Stress

KW - Urocortin-2

KW - Urocortin-3

KW - Urotensin

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BT - The Curated Reference Collection in Neuroscience and Biobehavioral Psychology

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ER -

Corticotropin releasing hormone (CRH) and urocortins are key central and peripheral regulators of stress, anxiety, energy balance and metabolism

Abstract

Keywords

ASJC Scopus subject areas

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