Corticotropin-releasing factor (CRF) is the most potent hypothalamic neuropeptide to induce the release of adrenocorticotropic hormone from the anterior pituitary gland, initiating a cascade of endocrine events collectively known as the neuroendocrine stress response. CRF is a member of a neuropeptide family that includes the urocortins Ucn1, Ucn2, and Ucn3. These neuropeptides signal via two CRF receptors and are subjected to the modulatory actions of several soluble binding proteins. CRF and urocortins play key roles in the control of the stress response and are involved in arousal and anxiety, depression, feeding behavior, energy balance, digestion, cardiovascular activity, and pregnancy.
- Cardiovascular system
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