Corticosterone was administered sc daily on days 11–14 to pregnant A/J female mice, 5 mg producing 80% isolated cleft palate, 2.5 mg, 31%, and 1.25 mg, 6%. The prenatal death rate was not increased by corticosterone in litters with surviving offspring but did result in an increased frequency of totally resorbed litters. Among fetuses treated with corticosterone there was a dose related increase in hemorrhagic pigmentation of the fetal sac. Damage to the fetal sac by corticosteroids may be a basis for their teratogenic action.
ASJC Scopus subject areas
- Developmental Biology
- Health, Toxicology and Mutagenesis