Corticosterone‐induced isolated cleft palate in A/J mice

Robert M. Hackman, Kenneth S. Brown

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Corticosterone was administered sc daily on days 11–14 to pregnant A/J female mice, 5 mg producing 80% isolated cleft palate, 2.5 mg, 31%, and 1.25 mg, 6%. The prenatal death rate was not increased by corticosterone in litters with surviving offspring but did result in an increased frequency of totally resorbed litters. Among fetuses treated with corticosterone there was a dose related increase in hemorrhagic pigmentation of the fetal sac. Damage to the fetal sac by corticosteroids may be a basis for their teratogenic action.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalTeratology
Volume6
Issue number3
DOIs
StatePublished - 1972
Externally publishedYes

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis

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