Abstract
In this chapter, we review evidence that the cortical pathways to the hippocampus appear to extend from two large-scale cortical systems: a posterior medial (PM) system that includes the parahippocampal cortex and retrosplenial cortex, and an anterior temporal (AT) system that includes the perirhinal cortex. This "PMAT" framework accounts for differences in the anatomical and functional connectivity of the medial temporal lobes, which may underpin differences in cognitive function between the systems. The PM and AT systems make distinct contributions to memory and to other cognitive domains, and convergent findings suggest that they are involved in processing information about contexts and items, respectively. In order to support the full complement of memory-guided behavior, the two systems must interact, and the hippocampal and ventromedial prefrontal cortex may serve as sites of integration between the two systems. We conclude that when considering the "connected hippocampus," inquiry should extend beyond the medial temporal lobes to include the large-scale cortical systems of which they are a part.
| Original language | English (US) |
|---|---|
| Title of host publication | Progress in Brain Research |
| Publisher | Elsevier |
| Pages | 45-64 |
| Number of pages | 20 |
| Volume | 219 |
| ISBN (Print) | 9780444635495 |
| DOIs | |
| State | Published - 2015 |
Publication series
| Name | Progress in Brain Research |
|---|---|
| Volume | 219 |
| ISSN (Print) | 00796123 |
| ISSN (Electronic) | 18757855 |
Fingerprint
Keywords
- Default network
- Episodic memory
- Functional connectivity
- Medial temporal lobes
- Parahippocampal cortex
- Perirhinal cortex
- Retrosplenial cortex
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Cortico-hippocampal systems involved in memory and cognition : The PMAT framework. / Ritchey, Maureen; Libby, Laura A.; Ranganath, Charan.
Progress in Brain Research. Vol. 219 Elsevier, 2015. p. 45-64 (Progress in Brain Research; Vol. 219).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Cortico-hippocampal systems involved in memory and cognition
T2 - The PMAT framework
AU - Ritchey, Maureen
AU - Libby, Laura A.
AU - Ranganath, Charan
PY - 2015
Y1 - 2015
N2 - In this chapter, we review evidence that the cortical pathways to the hippocampus appear to extend from two large-scale cortical systems: a posterior medial (PM) system that includes the parahippocampal cortex and retrosplenial cortex, and an anterior temporal (AT) system that includes the perirhinal cortex. This "PMAT" framework accounts for differences in the anatomical and functional connectivity of the medial temporal lobes, which may underpin differences in cognitive function between the systems. The PM and AT systems make distinct contributions to memory and to other cognitive domains, and convergent findings suggest that they are involved in processing information about contexts and items, respectively. In order to support the full complement of memory-guided behavior, the two systems must interact, and the hippocampal and ventromedial prefrontal cortex may serve as sites of integration between the two systems. We conclude that when considering the "connected hippocampus," inquiry should extend beyond the medial temporal lobes to include the large-scale cortical systems of which they are a part.
AB - In this chapter, we review evidence that the cortical pathways to the hippocampus appear to extend from two large-scale cortical systems: a posterior medial (PM) system that includes the parahippocampal cortex and retrosplenial cortex, and an anterior temporal (AT) system that includes the perirhinal cortex. This "PMAT" framework accounts for differences in the anatomical and functional connectivity of the medial temporal lobes, which may underpin differences in cognitive function between the systems. The PM and AT systems make distinct contributions to memory and to other cognitive domains, and convergent findings suggest that they are involved in processing information about contexts and items, respectively. In order to support the full complement of memory-guided behavior, the two systems must interact, and the hippocampal and ventromedial prefrontal cortex may serve as sites of integration between the two systems. We conclude that when considering the "connected hippocampus," inquiry should extend beyond the medial temporal lobes to include the large-scale cortical systems of which they are a part.
KW - Default network
KW - Episodic memory
KW - Functional connectivity
KW - Medial temporal lobes
KW - Parahippocampal cortex
KW - Perirhinal cortex
KW - Retrosplenial cortex
UR - http://www.scopus.com/inward/record.url?scp=84943348764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943348764&partnerID=8YFLogxK
U2 - 10.1016/bs.pbr.2015.04.001
DO - 10.1016/bs.pbr.2015.04.001
M3 - Chapter
AN - SCOPUS:84943348764
SN - 9780444635495
VL - 219
T3 - Progress in Brain Research
SP - 45
EP - 64
BT - Progress in Brain Research
PB - Elsevier
ER -