Cortico-hippocampal systems involved in memory and cognition: The PMAT framework

Maureen Ritchey, Laura A. Libby, Charan Ranganath

Research output: Chapter in Book/Report/Conference proceedingChapter

76 Scopus citations

Abstract

In this chapter, we review evidence that the cortical pathways to the hippocampus appear to extend from two large-scale cortical systems: a posterior medial (PM) system that includes the parahippocampal cortex and retrosplenial cortex, and an anterior temporal (AT) system that includes the perirhinal cortex. This "PMAT" framework accounts for differences in the anatomical and functional connectivity of the medial temporal lobes, which may underpin differences in cognitive function between the systems. The PM and AT systems make distinct contributions to memory and to other cognitive domains, and convergent findings suggest that they are involved in processing information about contexts and items, respectively. In order to support the full complement of memory-guided behavior, the two systems must interact, and the hippocampal and ventromedial prefrontal cortex may serve as sites of integration between the two systems. We conclude that when considering the "connected hippocampus," inquiry should extend beyond the medial temporal lobes to include the large-scale cortical systems of which they are a part.

Original languageEnglish (US)
Title of host publicationProgress in Brain Research
PublisherElsevier
Pages45-64
Number of pages20
Volume219
ISBN (Print)9780444635495
DOIs
StatePublished - 2015

Publication series

NameProgress in Brain Research
Volume219
ISSN (Print)00796123
ISSN (Electronic)18757855

Keywords

  • Default network
  • Episodic memory
  • Functional connectivity
  • Medial temporal lobes
  • Parahippocampal cortex
  • Perirhinal cortex
  • Retrosplenial cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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    Ritchey, M., Libby, L. A., & Ranganath, C. (2015). Cortico-hippocampal systems involved in memory and cognition: The PMAT framework. In Progress in Brain Research (Vol. 219, pp. 45-64). (Progress in Brain Research; Vol. 219). Elsevier. https://doi.org/10.1016/bs.pbr.2015.04.001