Cortical thickness mediates the effect of β-amyloid on episodic memory

Sylvia Villeneuve, Bruce R Reed, Miranka Wirth, Claudia M. Haase, Cindee M. Madison, Nagehan Ayakta, Wendy Mack, Dan M Mungas, Helena C. Chui, Charles DeCarli, Michael W. Weiner, William J. Jagust

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: To investigate the associations among β-amyloid (Aβ), cortical thickness, and episodic memory in a cohort of cognitively normal to mildly impaired individuals at increased risk of vascular disease. Methods: In 67 subjects specifically recruited to span a continuum of cognitive function and vascular risk, we measured brain Ab deposition using [11C] Pittsburgh compound B-PET imaging and cortical thickness using MRI. Episodic memory was tested using a standardized composite score of verbal memory, and vascular risk was quantified using the Framingham Coronary Risk Profile index. Results: Increased Ab was associated with cortical thinning, notably in frontoparietal regions. This relationship was strongest in persons with high Ab deposition. Increased Ab was also associated with lower episodic memory performance. Cortical thickness was found to mediate the relationship between Ab and memory performance. While age had a marginal effect on these associations, the relationship between Ab and cortical thickness was eliminated after controlling for vascular risk except when examined in only Pittsburgh compound B-positive subjects, in whom Ab remained associated with thinner cortex in precuneus and occipital lobe. In addition, only the precuneus was found to mediate the relationship between Ab and memory after controlling for vascular risk. Conclusion: These results suggest strong links among Ab, cortical thickness, and memory. They highlight that, in individuals without dementia, vascular risk also contributes to cortical thickness and influences the relationships among Ab, cortical thickness, and memory.

Original languageEnglish (US)
Pages (from-to)761-767
Number of pages7
JournalNeurology
Volume82
Issue number9
DOIs
StatePublished - Mar 4 2014

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Episodic Memory
Amyloid
Blood Vessels
Parietal Lobe
Occipital Lobe
Vascular Dementia
Cortical Thickness
Vascular Diseases
Cognition
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Villeneuve, S., Reed, B. R., Wirth, M., Haase, C. M., Madison, C. M., Ayakta, N., ... Jagust, W. J. (2014). Cortical thickness mediates the effect of β-amyloid on episodic memory. Neurology, 82(9), 761-767. https://doi.org/10.1212/WNL.0000000000000170

Cortical thickness mediates the effect of β-amyloid on episodic memory. / Villeneuve, Sylvia; Reed, Bruce R; Wirth, Miranka; Haase, Claudia M.; Madison, Cindee M.; Ayakta, Nagehan; Mack, Wendy; Mungas, Dan M; Chui, Helena C.; DeCarli, Charles; Weiner, Michael W.; Jagust, William J.

In: Neurology, Vol. 82, No. 9, 04.03.2014, p. 761-767.

Research output: Contribution to journalArticle

Villeneuve, S, Reed, BR, Wirth, M, Haase, CM, Madison, CM, Ayakta, N, Mack, W, Mungas, DM, Chui, HC, DeCarli, C, Weiner, MW & Jagust, WJ 2014, 'Cortical thickness mediates the effect of β-amyloid on episodic memory', Neurology, vol. 82, no. 9, pp. 761-767. https://doi.org/10.1212/WNL.0000000000000170
Villeneuve S, Reed BR, Wirth M, Haase CM, Madison CM, Ayakta N et al. Cortical thickness mediates the effect of β-amyloid on episodic memory. Neurology. 2014 Mar 4;82(9):761-767. https://doi.org/10.1212/WNL.0000000000000170
Villeneuve, Sylvia ; Reed, Bruce R ; Wirth, Miranka ; Haase, Claudia M. ; Madison, Cindee M. ; Ayakta, Nagehan ; Mack, Wendy ; Mungas, Dan M ; Chui, Helena C. ; DeCarli, Charles ; Weiner, Michael W. ; Jagust, William J. / Cortical thickness mediates the effect of β-amyloid on episodic memory. In: Neurology. 2014 ; Vol. 82, No. 9. pp. 761-767.
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