Abstract
A method for obtaining nuclear magnetic resonance (NMR) spectroscopic signals confined to the cerebral cortex in rat using a cortical coil constructed based on the principles of the zig-zag coil is described. We obtained 31P NMR spectra of normal cerebral cortex and cold-induced injured cortex using this cortical coil. The cortical coil clearly demonstrated an increase in inorganic phosphate (P(i)) confined to cerebral cortex which, by contrast, the convential planar surface coil failed to detect. There are significant metabolic differences between cortex and subcortical tissues. The technique described here, capable of assessing corrtical metabolism in vivo without contamination by the underlying tissue, has substantial application to studies of cerebral metabolism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 364-368 |
| Number of pages | 5 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Cortical spectroscopy : Localized spectroscopy of the cerebral cortex in rats. / Houkin, K.; Nakada, T.; Suzuki, N.; Kwee, Ingrid.
In: Magnetic Resonance in Medicine, Vol. 12, No. 3, 1989, p. 364-368.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cortical spectroscopy
T2 - Localized spectroscopy of the cerebral cortex in rats
AU - Houkin, K.
AU - Nakada, T.
AU - Suzuki, N.
AU - Kwee, Ingrid
PY - 1989
Y1 - 1989
N2 - A method for obtaining nuclear magnetic resonance (NMR) spectroscopic signals confined to the cerebral cortex in rat using a cortical coil constructed based on the principles of the zig-zag coil is described. We obtained 31P NMR spectra of normal cerebral cortex and cold-induced injured cortex using this cortical coil. The cortical coil clearly demonstrated an increase in inorganic phosphate (P(i)) confined to cerebral cortex which, by contrast, the convential planar surface coil failed to detect. There are significant metabolic differences between cortex and subcortical tissues. The technique described here, capable of assessing corrtical metabolism in vivo without contamination by the underlying tissue, has substantial application to studies of cerebral metabolism.
AB - A method for obtaining nuclear magnetic resonance (NMR) spectroscopic signals confined to the cerebral cortex in rat using a cortical coil constructed based on the principles of the zig-zag coil is described. We obtained 31P NMR spectra of normal cerebral cortex and cold-induced injured cortex using this cortical coil. The cortical coil clearly demonstrated an increase in inorganic phosphate (P(i)) confined to cerebral cortex which, by contrast, the convential planar surface coil failed to detect. There are significant metabolic differences between cortex and subcortical tissues. The technique described here, capable of assessing corrtical metabolism in vivo without contamination by the underlying tissue, has substantial application to studies of cerebral metabolism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024841762&partnerID=8YFLogxK
U2 - 10.1002/mrm.1910120308
DO - 10.1002/mrm.1910120308
M3 - Article
VL - 12
SP - 364
EP - 368
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 3
ER -