Cortical spectroscopy: Localized spectroscopy of the cerebral cortex in rats

K. Houkin, T. Nakada, N. Suzuki, Ingrid Kwee

Research output: Contribution to journalArticle

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A method for obtaining nuclear magnetic resonance (NMR) spectroscopic signals confined to the cerebral cortex in rat using a cortical coil constructed based on the principles of the zig-zag coil is described. We obtained 31P NMR spectra of normal cerebral cortex and cold-induced injured cortex using this cortical coil. The cortical coil clearly demonstrated an increase in inorganic phosphate (P(i)) confined to cerebral cortex which, by contrast, the convential planar surface coil failed to detect. There are significant metabolic differences between cortex and subcortical tissues. The technique described here, capable of assessing corrtical metabolism in vivo without contamination by the underlying tissue, has substantial application to studies of cerebral metabolism.

Original languageEnglish (US)
Pages (from-to)364-368
Number of pages5
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - 1989


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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