Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

Stephen C Noctor, Veronica Martinez-Cerdeno, Lidija Ivic, Arnold R. Kriegstein

Research output: Contribution to journalArticle

1369 Citations (Scopus)

Abstract

Precise patterns of cell division and migration are crucial to transform the neuroepithelium of the embryonic forebrain into the adult cerebral cortex. Using time-lapse imaging of clonal cells in rat cortex over several generations, we show here that neurons are generated in two proliferative zones by distinct patterns of division. Neurons arise directly from radial glial cells in the ventricular zone (VZ) and indirectly from intermediate progenitor cells in the subventricular zone (SVZ). Furthermore, newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate. These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration.

Original languageEnglish (US)
Pages (from-to)136-144
Number of pages9
JournalNature Neuroscience
Volume7
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

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Neurons
Cerebral Cortex
Time-Lapse Imaging
Ependymoglial Cells
Lateral Ventricles
Neurogenesis
Prosencephalon
Cell Division
Cell Movement
Stem Cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. / Noctor, Stephen C; Martinez-Cerdeno, Veronica; Ivic, Lidija; Kriegstein, Arnold R.

In: Nature Neuroscience, Vol. 7, No. 2, 02.2004, p. 136-144.

Research output: Contribution to journalArticle

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