Abstract
Rationale and Objectives. This study was conducted to define and characterize magnetic resonance (MR) contrast medium enhancement of the renal cortex, medulla, and pelvocaliceal system in normal and hydronephrotic kidneys with and without furosemide administration. Materials and Methods. In 30 subjects known or suspected to have unilateral hydronephrosis and normal serum creatinine levels, multiple timed sets of coronal fast spoiled gradient-echo images were acquired before and after contrast medium administration. MR renograms were derived from changes in the signal intensity (SI) of the cortex, medulla, and pelvocaliceal system. Ten subjects received 40 mg of intravenous furosemide approximately 10 minutes before contrast medium administration. Results. The following values were significantly different between subjects who were given furosemide and those who were not: the peak cortical, medullary, and pelvocaliceal system SIs measured in the normal kidneys during the 4 1/2 minutes following contrast medium administration (163.2 ± 17.7 [mean arbitrary units plus or minus standard error] vs 120.5 ± 10.2 [P = .033], 155.5 ± 18.8 vs 111.5 ± 9.4 [P = .025], and 332.5 ± 27.2 vs 229.3 ± 31.9 [P = .026], respectively); the crossover time between the SI curves of the pelvocaliceal system and the medulla in the normal kidney (2.45 minutes ± 0.2 vs 3.27 minutes ± 0.25 [P = .02]); and the peak SIs of the cortex, medulla, and pelvocaliceal system in the unilateral obstructive hydronephrotic kidneys throughout the first 4 1/2 minutes after contrast medium administration (174.6 ± 16.4 vs 90.6 ± 13.7 [P = .003], 117.6 ± 14.1 vs 86.7 ± 11.8 [P = .015], and 337.2 ± 41.4 vs 143.1 ± 74.4 [P = .034], respectively). Conclusion. MR renography can be used to depict three separate components of renal enhancement: cortical, medullary, and pelvocaliceal. Furosemide-induced diuresis increases renal parenchymal and pelvocaliceal SI and urinary flow rates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 725-738 |
| Number of pages | 14 |
| Journal | Academic Radiology |
| Volume | 10 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2003 |
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Keywords
- Hydronephrosis
- Kidney, MR
- Kidney, stenosis or obstruction
- Magnetic resonance (MR), contrast enhancement
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Cortical, medullary, and pelvocaliceal MR renography with and without diuretic modification. / Katzberg, Richard W; Ivanovic, Marija; Buonocore, Michael H.; Brock, John M.; Ryan, John M.
In: Academic Radiology, Vol. 10, No. 7, 01.07.2003, p. 725-738.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cortical, medullary, and pelvocaliceal MR renography with and without diuretic modification
AU - Katzberg, Richard W
AU - Ivanovic, Marija
AU - Buonocore, Michael H.
AU - Brock, John M.
AU - Ryan, John M.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Rationale and Objectives. This study was conducted to define and characterize magnetic resonance (MR) contrast medium enhancement of the renal cortex, medulla, and pelvocaliceal system in normal and hydronephrotic kidneys with and without furosemide administration. Materials and Methods. In 30 subjects known or suspected to have unilateral hydronephrosis and normal serum creatinine levels, multiple timed sets of coronal fast spoiled gradient-echo images were acquired before and after contrast medium administration. MR renograms were derived from changes in the signal intensity (SI) of the cortex, medulla, and pelvocaliceal system. Ten subjects received 40 mg of intravenous furosemide approximately 10 minutes before contrast medium administration. Results. The following values were significantly different between subjects who were given furosemide and those who were not: the peak cortical, medullary, and pelvocaliceal system SIs measured in the normal kidneys during the 4 1/2 minutes following contrast medium administration (163.2 ± 17.7 [mean arbitrary units plus or minus standard error] vs 120.5 ± 10.2 [P = .033], 155.5 ± 18.8 vs 111.5 ± 9.4 [P = .025], and 332.5 ± 27.2 vs 229.3 ± 31.9 [P = .026], respectively); the crossover time between the SI curves of the pelvocaliceal system and the medulla in the normal kidney (2.45 minutes ± 0.2 vs 3.27 minutes ± 0.25 [P = .02]); and the peak SIs of the cortex, medulla, and pelvocaliceal system in the unilateral obstructive hydronephrotic kidneys throughout the first 4 1/2 minutes after contrast medium administration (174.6 ± 16.4 vs 90.6 ± 13.7 [P = .003], 117.6 ± 14.1 vs 86.7 ± 11.8 [P = .015], and 337.2 ± 41.4 vs 143.1 ± 74.4 [P = .034], respectively). Conclusion. MR renography can be used to depict three separate components of renal enhancement: cortical, medullary, and pelvocaliceal. Furosemide-induced diuresis increases renal parenchymal and pelvocaliceal SI and urinary flow rates.
AB - Rationale and Objectives. This study was conducted to define and characterize magnetic resonance (MR) contrast medium enhancement of the renal cortex, medulla, and pelvocaliceal system in normal and hydronephrotic kidneys with and without furosemide administration. Materials and Methods. In 30 subjects known or suspected to have unilateral hydronephrosis and normal serum creatinine levels, multiple timed sets of coronal fast spoiled gradient-echo images were acquired before and after contrast medium administration. MR renograms were derived from changes in the signal intensity (SI) of the cortex, medulla, and pelvocaliceal system. Ten subjects received 40 mg of intravenous furosemide approximately 10 minutes before contrast medium administration. Results. The following values were significantly different between subjects who were given furosemide and those who were not: the peak cortical, medullary, and pelvocaliceal system SIs measured in the normal kidneys during the 4 1/2 minutes following contrast medium administration (163.2 ± 17.7 [mean arbitrary units plus or minus standard error] vs 120.5 ± 10.2 [P = .033], 155.5 ± 18.8 vs 111.5 ± 9.4 [P = .025], and 332.5 ± 27.2 vs 229.3 ± 31.9 [P = .026], respectively); the crossover time between the SI curves of the pelvocaliceal system and the medulla in the normal kidney (2.45 minutes ± 0.2 vs 3.27 minutes ± 0.25 [P = .02]); and the peak SIs of the cortex, medulla, and pelvocaliceal system in the unilateral obstructive hydronephrotic kidneys throughout the first 4 1/2 minutes after contrast medium administration (174.6 ± 16.4 vs 90.6 ± 13.7 [P = .003], 117.6 ± 14.1 vs 86.7 ± 11.8 [P = .015], and 337.2 ± 41.4 vs 143.1 ± 74.4 [P = .034], respectively). Conclusion. MR renography can be used to depict three separate components of renal enhancement: cortical, medullary, and pelvocaliceal. Furosemide-induced diuresis increases renal parenchymal and pelvocaliceal SI and urinary flow rates.
KW - Hydronephrosis
KW - Kidney, MR
KW - Kidney, stenosis or obstruction
KW - Magnetic resonance (MR), contrast enhancement
UR - http://www.scopus.com/inward/record.url?scp=0037785124&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037785124&partnerID=8YFLogxK
U2 - 10.1016/S1076-6332(03)80118-6
DO - 10.1016/S1076-6332(03)80118-6
M3 - Article
C2 - 12862282
AN - SCOPUS:0037785124
VL - 10
SP - 725
EP - 738
JO - Academic Radiology
JF - Academic Radiology
SN - 1076-6332
IS - 7
ER -