Cortical malformations and epilepsy

Philip A Schwartzkroin, Christopher A. Walsh

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Brain malformations, resulting from aberrant patterns of brain development, are highly correlated with childhood seizure syndromes, as well as with cognitive disabilities and other neurological disorders. The structural malformations, often referred to as cortical dysplasia, are extremely varied, reflecting diverse underlying processes and critical timing of the developmental aberration. Recent studies have revealed a genetic basis for many forms of dysplasia. Gene mutations responsible for such common forms of dysplasia as lissencephaly and tuberous sclerosis have been identified, and investigators are beginning to understand how these gene mutations interrupt and/or misdirect the normal developmental pattern. Laboratory investigations, using animal models of cortical dysplasia, are beginning to elucidate how these structural malformations give rise to epilepsy and other functional pathologies. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)268-280
Number of pages13
JournalMental Retardation and Developmental Disabilities Research Reviews
Issue number4
StatePublished - 2000
Externally publishedYes


  • Animal models
  • Brain development
  • Dysplasia
  • Gene mutations
  • Lissencephaly
  • Seizure mechanisms
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Genetics(clinical)


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