Cortical kindled seizures: Modification by excitant and depressant drugs

J. F. Bowyer, Timothy E Albertson, W. D. Winters

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The effects of several excitant-convulsants, cataleptic anesthetics, and γ-acetylenic γ-aminobutyric acid (GABA) were tested on seizures kindled by repetitive electrical stimulation of the motor cortex in the rat. A dose response was determined for each drug. For most of the drugs, the doses tested ranged from those causing some signs of behavioral excitation to those inducing epileptoid activity. None of the excitant-convulsants, including strychnine, physostigmine, amphetamine, bicuculline, or pentylenetetrazol, increased the afterdischarge duration (AD) or behavioral response (BR) of the partially developed (PD-KCS) or generalized fully developed (KCS) kindled cortical seizures. Whereas pentylenetetrazol had no effect on the PD-KCS, it has been previously shown to increase significantly the AD and BR of the developing or partially developed amygdaloid kindled seizures. Lidocaine, γ-butyrolactone, γ-acetylenic GABA, phencyclidine, and ketamine inhibited the AD of the KCS by ≥ 80%. Lidocaine, phencyclidine, and ketamine decreased whereas γ-butyrolactone and γ-acetylenic GABA increased the AD of the PD-KCS. The ability of γ-butyrolactone and γ-acetylenic GABA to potentiate the PD-KCS while inhibiting the KCS presents a paradox not readily explained. The authors' results combined with previous reports of the effects of γ-butyrolactone and γ-acetylenic GABA on amygdaloid kindled seizures indicate that the KCS is more susceptible to GABAnergic and cataleptic inhibition than is the fully developed amygdaloid kindled seizures. The differences between the response of cortical kindled and that of amygdaloid kindled seizures to some of the drugs tested may indicate differences in the physiological and biochemical mechanisms involved in producing these seizures.

Original languageEnglish (US)
Pages (from-to)356-367
Number of pages12
JournalEpilepsia
Volume24
Issue number3
StatePublished - 1983

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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