Cortical contributions to impaired contour integration in schizophrenia

Steven M. Silverstein, Michael P. Harms, Cameron S Carter, James M. Gold, Brian P. Keane, Angus MacDonald, John D Ragland, Deanna M. Barch

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: Visual perceptual organization impairments in schizophrenia (SCZ) are well established, but their neurobiological bases are not. The current study used the previously validated Jittered Orientation Visual Integration (JOVI) task, along with fMRI, to examine the neural basis of contour integration (CI), and its impairment in SCZ. CI is an aspect of perceptual organization in which multiple distinct oriented elements are grouped into a single continuous boundary or shape. Methods: On the JOVI, five levels of orientational jitter were added to non-contiguous closed contour elements embedded in background noise to progressively increase the difficulty in perceiving contour elements as left- or right-pointing ovals. Multi-site fMRI data were analyzed for 56 healthy control subjects and 47 people with SCZ. Results: SCZ patients demonstrated poorer CI, and this was associated with increased activation in regions involved in global shape processing and visual attention, namely the lateral occipital complex and superior parietal lobules. There were no brain regions where controls demonstrated more activation than patients. Conclusions: CI impairment in this sample of outpatients with SCZ was related to excessive activation in regions associated with object processing and allocation of visual-spatial attention. There was no evidence for basic impairments in contour element linking in the fMRI data. The latter may be limited to poor outcome patients, where more extensive structural and functional changes in the occipital lobe have been observed.

Original languageEnglish (US)
Pages (from-to)469-480
Number of pages12
JournalNeuropsychologia
Volume75
DOIs
StatePublished - Aug 1 2015

Fingerprint

Schizophrenia
Magnetic Resonance Imaging
Occipital Lobe
Parietal Lobe
Noise
Healthy Volunteers
Outpatients
Brain
Impairment
Functional Magnetic Resonance Imaging
Activation

Keywords

  • Contour integration
  • FMRI
  • Lateral occipital complex
  • Perception
  • Perceptual organization
  • Schizophrenia
  • Vision

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Silverstein, S. M., Harms, M. P., Carter, C. S., Gold, J. M., Keane, B. P., MacDonald, A., ... Barch, D. M. (2015). Cortical contributions to impaired contour integration in schizophrenia. Neuropsychologia, 75, 469-480. https://doi.org/10.1016/j.neuropsychologia.2015.07.003

Cortical contributions to impaired contour integration in schizophrenia. / Silverstein, Steven M.; Harms, Michael P.; Carter, Cameron S; Gold, James M.; Keane, Brian P.; MacDonald, Angus; Ragland, John D; Barch, Deanna M.

In: Neuropsychologia, Vol. 75, 01.08.2015, p. 469-480.

Research output: Contribution to journalArticle

Silverstein, Steven M. ; Harms, Michael P. ; Carter, Cameron S ; Gold, James M. ; Keane, Brian P. ; MacDonald, Angus ; Ragland, John D ; Barch, Deanna M. / Cortical contributions to impaired contour integration in schizophrenia. In: Neuropsychologia. 2015 ; Vol. 75. pp. 469-480.
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