Abstract
Background: Thyroid dysfunction is common after radiotherapy (RT) for patients with head and neck cancers. We attempted to discover RT dose parameters that correspond with RT-induced thyroid dysfunction. Methods: Records of 102 patients who received RT from 2008 to 2010 were reviewed with respect to thyroid function. Abnormalities were grouped in 2 ways: (1) none, transient, or permanent; and (2) overt or subclinical. Results: At median follow-up of 33.5 months, incidence of any thyroid abnormality was 39.2% (women vs men – 50% vs 35%). Permanent dysfunction was seen in 24.5% with higher incidence in women versus men (42.9% vs 17.6%; p =.0081). Permanent abnormalities most strongly correlated with D50% (p =.0275). V50Gy also correlated with thyroid dysfunction post-RT (p =.0316). Concurrent chemotherapy increased permanent dysfunction (p =.0008). Conclusion: Achieving D50% <50 Gy, V50 <50%, and mean dose <54.58 Gy during RT planning may decrease the incidence; whereas female sex and concurrent chemotherapy seem to increase the risk of RT-induced hypothyroidism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 548-554 |
| Number of pages | 7 |
| Journal | Head and Neck |
| Volume | 39 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2017 |
Fingerprint
Keywords
- head and neck radiotherapy
- hypothyroidism
- radiation dose volume histogram (DVH)
- radiation toxicity
- thyroid abnormality
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Correlative study of dose to thyroid and incidence of subsequent dysfunction after head and neck radiation. / Ling, Stella; Bhatt, Aashish D.; Brown, Nicole V.; Nguyen, Phuong; Sipos, Jennifer A.; Chakravarti, Arnab; Rong, Yi.
In: Head and Neck, Vol. 39, No. 3, 01.03.2017, p. 548-554.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlative study of dose to thyroid and incidence of subsequent dysfunction after head and neck radiation
AU - Ling, Stella
AU - Bhatt, Aashish D.
AU - Brown, Nicole V.
AU - Nguyen, Phuong
AU - Sipos, Jennifer A.
AU - Chakravarti, Arnab
AU - Rong, Yi
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Background: Thyroid dysfunction is common after radiotherapy (RT) for patients with head and neck cancers. We attempted to discover RT dose parameters that correspond with RT-induced thyroid dysfunction. Methods: Records of 102 patients who received RT from 2008 to 2010 were reviewed with respect to thyroid function. Abnormalities were grouped in 2 ways: (1) none, transient, or permanent; and (2) overt or subclinical. Results: At median follow-up of 33.5 months, incidence of any thyroid abnormality was 39.2% (women vs men – 50% vs 35%). Permanent dysfunction was seen in 24.5% with higher incidence in women versus men (42.9% vs 17.6%; p =.0081). Permanent abnormalities most strongly correlated with D50% (p =.0275). V50Gy also correlated with thyroid dysfunction post-RT (p =.0316). Concurrent chemotherapy increased permanent dysfunction (p =.0008). Conclusion: Achieving D50% <50 Gy, V50 <50%, and mean dose <54.58 Gy during RT planning may decrease the incidence; whereas female sex and concurrent chemotherapy seem to increase the risk of RT-induced hypothyroidism.
AB - Background: Thyroid dysfunction is common after radiotherapy (RT) for patients with head and neck cancers. We attempted to discover RT dose parameters that correspond with RT-induced thyroid dysfunction. Methods: Records of 102 patients who received RT from 2008 to 2010 were reviewed with respect to thyroid function. Abnormalities were grouped in 2 ways: (1) none, transient, or permanent; and (2) overt or subclinical. Results: At median follow-up of 33.5 months, incidence of any thyroid abnormality was 39.2% (women vs men – 50% vs 35%). Permanent dysfunction was seen in 24.5% with higher incidence in women versus men (42.9% vs 17.6%; p =.0081). Permanent abnormalities most strongly correlated with D50% (p =.0275). V50Gy also correlated with thyroid dysfunction post-RT (p =.0316). Concurrent chemotherapy increased permanent dysfunction (p =.0008). Conclusion: Achieving D50% <50 Gy, V50 <50%, and mean dose <54.58 Gy during RT planning may decrease the incidence; whereas female sex and concurrent chemotherapy seem to increase the risk of RT-induced hypothyroidism.
KW - head and neck radiotherapy
KW - hypothyroidism
KW - radiation dose volume histogram (DVH)
KW - radiation toxicity
KW - thyroid abnormality
UR - http://www.scopus.com/inward/record.url?scp=85006166559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006166559&partnerID=8YFLogxK
U2 - 10.1002/hed.24643
DO - 10.1002/hed.24643
M3 - Article
VL - 39
SP - 548
EP - 554
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 0148-6403
IS - 3
ER -