Correlation of the appearance of γ-carboxyglutamic acid with the onset of mineralization in developing endochondral bone

Peter V. Hauschka; A Hari Reddi

doi:10.1016/0006-291X(80)90806-2

Correlation of the appearance of γ-carboxyglutamic acid with the onset of mineralization in developing endochondral bone

Peter V. Hauschka, A Hari Reddi

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

γ-Carboxyglutamic acid (Gla) is a constituent of the non-collagenous bone protein osteocalcin. The appearance of γ-carboxyglutamic acid during de novo differentiation and development of endochondral bone has been correlated with the onset of mineralization. Discrete stages of endochondral bone development were studied by subcutaneous implantation of demineralized rat diaphyseal bone matrix. Residual Gla in acid-demineralized bone matrix was lost rapidly on implantation. Gla levels were basal during mesenchymal cell proliferation (day 3) and chondrogenesis (days 5-7). Gla and calcium levels began to increase during cartilage mineralization (day 9) and continuously increased after day 10 concomitant with bone differentiation.

Original language	English (US)
Pages (from-to)	1037-1041
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	92
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(80)90806-2
State	Published - Feb 12 1980
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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abstract = "γ-Carboxyglutamic acid (Gla) is a constituent of the non-collagenous bone protein osteocalcin. The appearance of γ-carboxyglutamic acid during de novo differentiation and development of endochondral bone has been correlated with the onset of mineralization. Discrete stages of endochondral bone development were studied by subcutaneous implantation of demineralized rat diaphyseal bone matrix. Residual Gla in acid-demineralized bone matrix was lost rapidly on implantation. Gla levels were basal during mesenchymal cell proliferation (day 3) and chondrogenesis (days 5-7). Gla and calcium levels began to increase during cartilage mineralization (day 9) and continuously increased after day 10 concomitant with bone differentiation.",

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AU - Reddi, A Hari

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AB - γ-Carboxyglutamic acid (Gla) is a constituent of the non-collagenous bone protein osteocalcin. The appearance of γ-carboxyglutamic acid during de novo differentiation and development of endochondral bone has been correlated with the onset of mineralization. Discrete stages of endochondral bone development were studied by subcutaneous implantation of demineralized rat diaphyseal bone matrix. Residual Gla in acid-demineralized bone matrix was lost rapidly on implantation. Gla levels were basal during mesenchymal cell proliferation (day 3) and chondrogenesis (days 5-7). Gla and calcium levels began to increase during cartilage mineralization (day 9) and continuously increased after day 10 concomitant with bone differentiation.

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Correlation of the appearance of γ-carboxyglutamic acid with the onset of mineralization in developing endochondral bone

Abstract

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