Correlation of the appearance of γ-carboxyglutamic acid with the onset of mineralization in developing endochondral bone

Peter V. Hauschka, A Hari Reddi

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

γ-Carboxyglutamic acid (Gla) is a constituent of the non-collagenous bone protein osteocalcin. The appearance of γ-carboxyglutamic acid during de novo differentiation and development of endochondral bone has been correlated with the onset of mineralization. Discrete stages of endochondral bone development were studied by subcutaneous implantation of demineralized rat diaphyseal bone matrix. Residual Gla in acid-demineralized bone matrix was lost rapidly on implantation. Gla levels were basal during mesenchymal cell proliferation (day 3) and chondrogenesis (days 5-7). Gla and calcium levels began to increase during cartilage mineralization (day 9) and continuously increased after day 10 concomitant with bone differentiation.

Original languageEnglish (US)
Pages (from-to)1037-1041
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume92
Issue number3
DOIs
StatePublished - Feb 12 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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