Correlation of measures of regional lung ventilation from 4DCT vs. hyperpolarized helium-3 MR

Kai Ding, Kunlin Cao, Wilson Miller, Gary Christensen, Joseph Reinhardt, Stanley H Benedict, Bruce Libby, Ke Sheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Radiation induced pulmonary diseases can change the tissue material properties of lung parenchyma and the mechanics of the respiratory system. Recent advances in multi-detector-row CT (MDCT), 4DCT respiratory gating methods, and image processing techniques enable us to follow and measure those changes noninvasively during radiation therapy at a regional level. This study compares the 4DCT based ventilation measurement with the results from hyperpolarized helium-3 MR using the cumulative distribution function maps and the relative overlap (RO) statistic. We show that the similarity between the two measurements increases as the increase of the B-Spline grid spacing and Laplacian weighting which result a smoother ventilation map. The best similarity is found with weighting of 0.5 for linear elasticity and B-Spline grid spacing of 32 mm. Future work is to improve the lung image registration algorithm by incorporating hyperpolarized helium-3 MR information so as to improve its physiological modeling of the lung tissue deformation.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8317
DOIs
StatePublished - 2012
Externally publishedYes
EventMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 5 2012Feb 7 2012

Other

OtherMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/5/122/7/12

Keywords

  • 4DCT
  • Image registration
  • MRI
  • Pulmonary
  • Ventilation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Ding, K., Cao, K., Miller, W., Christensen, G., Reinhardt, J., Benedict, S. H., Libby, B., & Sheng, K. (2012). Correlation of measures of regional lung ventilation from 4DCT vs. hyperpolarized helium-3 MR. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8317). [83171E] https://doi.org/10.1117/12.912793