Correlation of marrow iron patterns with disease status of chronic myelogenous leukemia

Jeanna L Welborn, Jerry P. Lewis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Greater than 80% of patients in the stable phase of chronic myelogenous leukemia (CML) have no detectable stainable iron in the marrow yet have normar serum iron, total iron binding capacity, and serum ferritin values. We studied the pattern of marrow iron in 187 marrow aspirates from 67 patients with Philadelphia chromosome positive CML in the chronic, accelerated and blast crisis stages. Sequential marrow aspirates in 30 patients confirm that- the switch from negative iron to positive iron is coincident with the development of the accelerated phase of blast crisis of CML. Our data suggest that the pattern of marrow iron staining in CML is a useful prognostic indicator of the disease evolution.

Original languageEnglish (US)
Pages (from-to)469-475
Number of pages7
JournalLeukemia and Lymphoma
Volume10
Issue number6
DOIs
StatePublished - 1993

Fingerprint

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Iron
Bone Marrow
Blast Crisis
Leukemia, Myeloid, Chronic Phase
Philadelphia Chromosome
Ferritins
Serum
Staining and Labeling

Keywords

  • Chronic myelogenous leukemia
  • Disease evolution
  • Marrow iron

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Correlation of marrow iron patterns with disease status of chronic myelogenous leukemia. / Welborn, Jeanna L; Lewis, Jerry P.

In: Leukemia and Lymphoma, Vol. 10, No. 6, 1993, p. 469-475.

Research output: Contribution to journalArticle

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