Correlation of evoked potential and MRI findings in Wilson's disease

L. M. Selwa, C. W. Vanderzant, James A Brunberg, G. J. Brewer, I. Drury, A. Beydoun

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

We recorded brainstem auditory evoked potentials (BAEPs) and somatosensory evoked potentials to median nerve stimulation (MSEPs) within 10 days of brain MRI in 20 patients with Wilson's disease (WD). MRI was abnormal in 90% of patients, demonstrating symmetric striatum and brainstem lesions with or without thalamic lesions. MSEPs were abnormal in 65% of patients, usually showing bilaterally prolonged N/P13-N20 latencies. BAEPs were abnormal in 40%, most often with bilateral prolongation of the III-V latency. The III-V and N/P13-N20 interpeak latencies correlated significantly with the severity of MRI lesions in the caudal pons, rostral pons, and caudal midbrain. Our results indicate that subclinical sensory dysfunction is common in WD, and that auditory and somatosensory pathways are most severely affected at the brainstem level. Both the localization and severity of evoked potential abnormalities correspond closely to the morphologic changes in the pons and caudal midbrain shown by MRI.

Original languageEnglish (US)
Pages (from-to)2059-2064
Number of pages6
JournalNeurology
Volume43
Issue number10
StatePublished - Oct 1993
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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