Correlation between NT-proBNP and lipase levels according to the severity of chronic mitral valve disease in dogs

Jun Seok Park, Jae Hong Park, Kyoung Won Seo, Kun Ho Song

Research output: Contribution to journalArticle

Abstract

Chronic mitral valve disease (CMVD) is the most common cardiovascular disease in dogs, causing decreased cardiac output that results in poor tissue perfusion and tissue damage to kidneys, pancreas, and other organs. The purpose of this study was to evaluate the relationships between heart disease severity and N-terminal pro B-type natriuretic peptide (NT-proBNP) and lipase in dogs with CMVD, as well as to evaluate longitudinal changes in these values. A total of 84 dogs participated in this 2015 to 2017 study. Serum values of NT-proBNP and lipase were analyzed; radiography was used to measure the vertebral heart score and assess various echocardiographic values. NT-proBNP showed a strong positive correlation with increasing stage of heart disease; lipase showed a mild positive correlation with heart disease stage. When the three values (NT-proBNP, lipase and month) were continuously measured at 6-month intervals, all showed a correlation with the increasing length of the disease.

Original languageEnglish (US)
Article numbere43
JournalJournal of Veterinary Science
Volume20
Issue number4
DOIs
StatePublished - Jul 1 2019

Fingerprint

Dog Diseases
natriuretic peptides
Brain Natriuretic Peptide
Lipase
Mitral Valve
heart diseases
Heart Diseases
dogs
Dogs
cardiac output
radiography
pancreas
Radiography
Cardiac Output
disease severity
cardiovascular diseases
Pancreas
Cardiovascular Diseases
Perfusion
heart

Keywords

  • Dog
  • Lipase
  • Mitral valve disease
  • NT-proBNP

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Correlation between NT-proBNP and lipase levels according to the severity of chronic mitral valve disease in dogs. / Park, Jun Seok; Park, Jae Hong; Seo, Kyoung Won; Song, Kun Ho.

In: Journal of Veterinary Science, Vol. 20, No. 4, e43, 01.07.2019.

Research output: Contribution to journalArticle

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N2 - Chronic mitral valve disease (CMVD) is the most common cardiovascular disease in dogs, causing decreased cardiac output that results in poor tissue perfusion and tissue damage to kidneys, pancreas, and other organs. The purpose of this study was to evaluate the relationships between heart disease severity and N-terminal pro B-type natriuretic peptide (NT-proBNP) and lipase in dogs with CMVD, as well as to evaluate longitudinal changes in these values. A total of 84 dogs participated in this 2015 to 2017 study. Serum values of NT-proBNP and lipase were analyzed; radiography was used to measure the vertebral heart score and assess various echocardiographic values. NT-proBNP showed a strong positive correlation with increasing stage of heart disease; lipase showed a mild positive correlation with heart disease stage. When the three values (NT-proBNP, lipase and month) were continuously measured at 6-month intervals, all showed a correlation with the increasing length of the disease.

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