Correlation between liver volume, portal vascular anatomy, and hepatic perfusion in dogs with congenital portosystemic shunt before and after placement of ameroid constrictors

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Abstract

OBJECTIVE: To correlate changes in hepatic volume, hepatic perfusion, and vascular anatomy of dogs with congenital extrahepatic portosystemic shunts, before and after attenuation with an ameroid constrictor.

STUDY DESIGN: Prospective study.

ANIMALS: Dogs (n = 22) with congenital extrahepatic portosystemic shunts.

METHODS: CT angiography and perfusion scans were performed before and after attenuation of a portosystemic shunt with an ameroid constrictor. Changes in hepatic volume, hepatic perfusion, and vascular anatomy were measured. Portal scintigraphy was performed in 8 dogs preoperatively and 22 dogs postoperatively.

RESULTS: Dogs with smaller preoperative liver volumes had greater increases in liver volume postoperatively compared with those with larger preoperative liver volumes. Hepatic arterial fraction was increased in dogs preoperatively and returned to normal range after shunt attenuation, and was correlated with increase in liver size and decreased shunt fraction. Three dogs with no visible portal vasculature preoperatively developed portal branches postoperatively.

CONCLUSIONS: Dogs with smaller preoperative liver volumes had the largest postoperative increase in liver volume. Hepatic arterial perfusion and portal scintigraphy correlate with liver volume and are indicators of successful shunt attenuation. Dogs without visible vasculature on CT angiography had visible portal vasculature postoperatively.

Original languageEnglish (US)
Pages (from-to)926-934
Number of pages9
JournalVeterinary Surgery
Volume43
Issue number8
DOIs
StatePublished - Nov 1 2014

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Surgical Portasystemic Shunt
blood vessels
Blood Vessels
Anatomy
Perfusion
Dogs
liver
dogs
Liver
scintigraphy
ameroid
Perfusion Imaging
prospective studies
Radionuclide Imaging

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{f9a4defe9a504be9af6abcee4c4b93cc,
title = "Correlation between liver volume, portal vascular anatomy, and hepatic perfusion in dogs with congenital portosystemic shunt before and after placement of ameroid constrictors",
abstract = "OBJECTIVE: To correlate changes in hepatic volume, hepatic perfusion, and vascular anatomy of dogs with congenital extrahepatic portosystemic shunts, before and after attenuation with an ameroid constrictor.STUDY DESIGN: Prospective study.ANIMALS: Dogs (n = 22) with congenital extrahepatic portosystemic shunts.METHODS: CT angiography and perfusion scans were performed before and after attenuation of a portosystemic shunt with an ameroid constrictor. Changes in hepatic volume, hepatic perfusion, and vascular anatomy were measured. Portal scintigraphy was performed in 8 dogs preoperatively and 22 dogs postoperatively.RESULTS: Dogs with smaller preoperative liver volumes had greater increases in liver volume postoperatively compared with those with larger preoperative liver volumes. Hepatic arterial fraction was increased in dogs preoperatively and returned to normal range after shunt attenuation, and was correlated with increase in liver size and decreased shunt fraction. Three dogs with no visible portal vasculature preoperatively developed portal branches postoperatively.CONCLUSIONS: Dogs with smaller preoperative liver volumes had the largest postoperative increase in liver volume. Hepatic arterial perfusion and portal scintigraphy correlate with liver volume and are indicators of successful shunt attenuation. Dogs without visible vasculature on CT angiography had visible portal vasculature postoperatively.",
author = "Allison Zwingenberger and Leticia Daniel and Steffey, {Michele A} and Philipp Mayhew and Mayhew, {Kelli N.} and Culp, {William T} and Hunt, {Geraldine B}",
year = "2014",
month = "11",
day = "1",
doi = "10.1111/j.1532-950X.2014.12193.x",
language = "English (US)",
volume = "43",
pages = "926--934",
journal = "Veterinary Surgery",
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publisher = "Wiley-Blackwell",
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TY - JOUR

T1 - Correlation between liver volume, portal vascular anatomy, and hepatic perfusion in dogs with congenital portosystemic shunt before and after placement of ameroid constrictors

AU - Zwingenberger, Allison

AU - Daniel, Leticia

AU - Steffey, Michele A

AU - Mayhew, Philipp

AU - Mayhew, Kelli N.

AU - Culp, William T

AU - Hunt, Geraldine B

PY - 2014/11/1

Y1 - 2014/11/1

N2 - OBJECTIVE: To correlate changes in hepatic volume, hepatic perfusion, and vascular anatomy of dogs with congenital extrahepatic portosystemic shunts, before and after attenuation with an ameroid constrictor.STUDY DESIGN: Prospective study.ANIMALS: Dogs (n = 22) with congenital extrahepatic portosystemic shunts.METHODS: CT angiography and perfusion scans were performed before and after attenuation of a portosystemic shunt with an ameroid constrictor. Changes in hepatic volume, hepatic perfusion, and vascular anatomy were measured. Portal scintigraphy was performed in 8 dogs preoperatively and 22 dogs postoperatively.RESULTS: Dogs with smaller preoperative liver volumes had greater increases in liver volume postoperatively compared with those with larger preoperative liver volumes. Hepatic arterial fraction was increased in dogs preoperatively and returned to normal range after shunt attenuation, and was correlated with increase in liver size and decreased shunt fraction. Three dogs with no visible portal vasculature preoperatively developed portal branches postoperatively.CONCLUSIONS: Dogs with smaller preoperative liver volumes had the largest postoperative increase in liver volume. Hepatic arterial perfusion and portal scintigraphy correlate with liver volume and are indicators of successful shunt attenuation. Dogs without visible vasculature on CT angiography had visible portal vasculature postoperatively.

AB - OBJECTIVE: To correlate changes in hepatic volume, hepatic perfusion, and vascular anatomy of dogs with congenital extrahepatic portosystemic shunts, before and after attenuation with an ameroid constrictor.STUDY DESIGN: Prospective study.ANIMALS: Dogs (n = 22) with congenital extrahepatic portosystemic shunts.METHODS: CT angiography and perfusion scans were performed before and after attenuation of a portosystemic shunt with an ameroid constrictor. Changes in hepatic volume, hepatic perfusion, and vascular anatomy were measured. Portal scintigraphy was performed in 8 dogs preoperatively and 22 dogs postoperatively.RESULTS: Dogs with smaller preoperative liver volumes had greater increases in liver volume postoperatively compared with those with larger preoperative liver volumes. Hepatic arterial fraction was increased in dogs preoperatively and returned to normal range after shunt attenuation, and was correlated with increase in liver size and decreased shunt fraction. Three dogs with no visible portal vasculature preoperatively developed portal branches postoperatively.CONCLUSIONS: Dogs with smaller preoperative liver volumes had the largest postoperative increase in liver volume. Hepatic arterial perfusion and portal scintigraphy correlate with liver volume and are indicators of successful shunt attenuation. Dogs without visible vasculature on CT angiography had visible portal vasculature postoperatively.

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