Abstract
Male Sprague-Dawley rats were exposed on 7 consecutive days for 8 h a night to 0.6 ppm ozone, 10.8 ppm NO2 or a mixture of the two gases. Cumulative labeling indices were measured in the epithelium of the terminal bronchioles and the adjacent centriacinar region. An excellent correlation in labeling indices between the two sites was found. It is concluded that the labeling index in the terminal bronchioles represents a sensitive measurement for ozone-induced lung injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-28 |
| Number of pages | 4 |
| Journal | Toxicology Letters |
| Volume | 80 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - 1995 |
Keywords
- Centriacinar region
- Labeling indices
- Nitrogen dioxide
- Ozone
- Terminal bronchioles
ASJC Scopus subject areas
- Toxicology
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Cite this
Lee, C., Rajini, P., Pinkerton, K. E., & Witschi, H. (1995). Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants. Toxicology Letters, 80(1-3), 25-28. https://doi.org/10.1016/0378-4274(95)03258-M