Abstract
Male Sprague-Dawley rats were exposed on 7 consecutive days for 8 h a night to 0.6 ppm ozone, 10.8 ppm NO2 or a mixture of the two gases. Cumulative labeling indices were measured in the epithelium of the terminal bronchioles and the adjacent centriacinar region. An excellent correlation in labeling indices between the two sites was found. It is concluded that the labeling index in the terminal bronchioles represents a sensitive measurement for ozone-induced lung injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-28 |
| Number of pages | 4 |
| Journal | Toxicology Letters |
| Volume | 80 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - 1995 |
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Keywords
- Centriacinar region
- Labeling indices
- Nitrogen dioxide
- Ozone
- Terminal bronchioles
ASJC Scopus subject areas
- Toxicology
Cite this
Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants. / Lee, Chanhung; Rajini, Padmanabhan; Pinkerton, Kent E; Witschi, Hanspeter.
In: Toxicology Letters, Vol. 80, No. 1-3, 1995, p. 25-28.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants
AU - Lee, Chanhung
AU - Rajini, Padmanabhan
AU - Pinkerton, Kent E
AU - Witschi, Hanspeter
PY - 1995
Y1 - 1995
N2 - Male Sprague-Dawley rats were exposed on 7 consecutive days for 8 h a night to 0.6 ppm ozone, 10.8 ppm NO2 or a mixture of the two gases. Cumulative labeling indices were measured in the epithelium of the terminal bronchioles and the adjacent centriacinar region. An excellent correlation in labeling indices between the two sites was found. It is concluded that the labeling index in the terminal bronchioles represents a sensitive measurement for ozone-induced lung injury.
AB - Male Sprague-Dawley rats were exposed on 7 consecutive days for 8 h a night to 0.6 ppm ozone, 10.8 ppm NO2 or a mixture of the two gases. Cumulative labeling indices were measured in the epithelium of the terminal bronchioles and the adjacent centriacinar region. An excellent correlation in labeling indices between the two sites was found. It is concluded that the labeling index in the terminal bronchioles represents a sensitive measurement for ozone-induced lung injury.
KW - Centriacinar region
KW - Labeling indices
KW - Nitrogen dioxide
KW - Ozone
KW - Terminal bronchioles
UR - http://www.scopus.com/inward/record.url?scp=0028784655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028784655&partnerID=8YFLogxK
U2 - 10.1016/0378-4274(95)03258-M
DO - 10.1016/0378-4274(95)03258-M
M3 - Article
C2 - 7482587
AN - SCOPUS:0028784655
VL - 80
SP - 25
EP - 28
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 1-3
ER -