Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants

Chanhung Lee, Padmanabhan Rajini, Kent E Pinkerton, Hanspeter Witschi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Male Sprague-Dawley rats were exposed on 7 consecutive days for 8 h a night to 0.6 ppm ozone, 10.8 ppm NO2 or a mixture of the two gases. Cumulative labeling indices were measured in the epithelium of the terminal bronchioles and the adjacent centriacinar region. An excellent correlation in labeling indices between the two sites was found. It is concluded that the labeling index in the terminal bronchioles represents a sensitive measurement for ozone-induced lung injury.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalToxicology Letters
Volume80
Issue number1-3
DOIs
StatePublished - 1995

Fingerprint

Bronchioles
Air Pollutants
Ozone
Oxidants
Labeling
Rats
Lung
Lung Injury
Sprague Dawley Rats
Epithelium
Gases

Keywords

  • Centriacinar region
  • Labeling indices
  • Nitrogen dioxide
  • Ozone
  • Terminal bronchioles

ASJC Scopus subject areas

  • Toxicology

Cite this

Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants. / Lee, Chanhung; Rajini, Padmanabhan; Pinkerton, Kent E; Witschi, Hanspeter.

In: Toxicology Letters, Vol. 80, No. 1-3, 1995, p. 25-28.

Research output: Contribution to journalArticle

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