Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants

Chanhung Lee; Padmanabhan Rajini; Kent E Pinkerton; Hanspeter Witschi

doi:10.1016/0378-4274(95)03258-M

Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants

Chanhung Lee, Padmanabhan Rajini, Kent E Pinkerton, Hanspeter Witschi

Pediatric Pulmonary

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Male Sprague-Dawley rats were exposed on 7 consecutive days for 8 h a night to 0.6 ppm ozone, 10.8 ppm NO₂ or a mixture of the two gases. Cumulative labeling indices were measured in the epithelium of the terminal bronchioles and the adjacent centriacinar region. An excellent correlation in labeling indices between the two sites was found. It is concluded that the labeling index in the terminal bronchioles represents a sensitive measurement for ozone-induced lung injury.

Original language	English (US)
Pages (from-to)	25-28
Number of pages	4
Journal	Toxicology Letters
Volume	80
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-4274(95)03258-M
State	Published - 1995

Keywords

Centriacinar region
Labeling indices
Nitrogen dioxide
Ozone
Terminal bronchioles

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(95)03258-M

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Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants. / Lee, Chanhung; Rajini, Padmanabhan; Pinkerton, Kent E; Witschi, Hanspeter.

In: Toxicology Letters, Vol. 80, No. 1-3, 1995, p. 25-28.

Research output: Contribution to journal › Article › peer-review

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AU - Witschi, Hanspeter

PY - 1995

Y1 - 1995

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AB - Male Sprague-Dawley rats were exposed on 7 consecutive days for 8 h a night to 0.6 ppm ozone, 10.8 ppm NO2 or a mixture of the two gases. Cumulative labeling indices were measured in the epithelium of the terminal bronchioles and the adjacent centriacinar region. An excellent correlation in labeling indices between the two sites was found. It is concluded that the labeling index in the terminal bronchioles represents a sensitive measurement for ozone-induced lung injury.

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Correlation between cumulative labeling indices measured in the terminal bronchioles and in the centriacinar region in the lungs of rats exposed to oxidant air pollutants

Abstract

Keywords

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