Correlation between computed tomographic brain scan abnormalities and neuropsychological function in children with symptomatic human immunodeficiency virus disease

P. Brouwers, C. DeCarli, L. Civitello, H. Moss, P. Wolters, Charles DeCarli

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Objective: To evaluate the clinical significance of computed tomographic brain scan abnormalities observed in children with symptomatic human immunodeficiency virus disease. Patients: Eighty-seven previously untreated children with symptomatic human immunodeficiency virus type 1 disease. Methods: General levels of cognitive functioning, obtained from age- appropriate intelligence tests, and social-emotional behavior were correlated with computed tomographic brain scan abnormality ratings. Results: A significant relation between computed tomographic brain scan abnormalities and cognitive dysfunction as well as aberrant behavior was found, which appeared stronger in (younger) vertically infected children compared with transfusion-infected patients. Calcifications, independent from the degree of brain atrophy, were associated with significantly greater delays in neurocognitive development. Conclusion: Computed tomographic brain scan abnormalities, even when mild, were of clinical significance, suggesting that human immunodeficiency virus-associated central nervous system compromise is a continuous process and that scans may be helpful at baseline in defining patients at risk and for monitoring them during therapy.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalArchives of Neurology
Volume52
Issue number1
StatePublished - 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)

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