Correlates of virulence in a frog-killing fungal pathogen: Evidence from a California amphibian decline

Jonah Piovia-Scott, Karen Pope, S. Joy Worth, Erica Bree Rosenblum, Thomas Poorten, Jeanine Refsnider, Louise A. Rollins-Smith, Laura K. Reinert, Heather L. Wells, Dan Rejmanek, Sharon Lawler, Janet E Foley

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The fungal pathogen Batrachochytrium dendrobatidis (Bd) has caused declines and extinctions in amphibians worldwide, and there is increasing evidence that some strains of this pathogen are more virulent than others. While a number of putative virulence factors have been identified, few studies link these factors to specific epizootic events. We documented a dramatic decline in juvenile frogs in a Bd-infected population of Cascades frogs (Rana cascadae) in the mountains of northern California and used a laboratory experiment to show that Bd isolated in the midst of this decline induced higher mortality than Bd isolated from a more stable population of the same species of frog. This highly virulent Bd isolate was more toxic to immune cells and attained higher density in liquid culture than comparable isolates. Genomic analyses revealed that this isolate is nested within the global panzootic lineage and exhibited unusual genomic patterns, including increased copy numbers of many chromosomal segments. This study integrates data from multiple sources to suggest specific phenotypic and genomic characteristics of the pathogen that may be linked to disease-related declines.

Original languageEnglish (US)
Pages (from-to)1570-1578
Number of pages9
JournalISME Journal
Volume9
Issue number7
DOIs
StatePublished - Jul 24 2015

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Chytridiomycota
Amphibians
virulence
frog
Anura
amphibian
Virulence
amphibians
frogs
genomics
pathogen
pathogens
Cascade Mountain region
Rana
Ranidae
extinction
mountains
Poisons
Information Storage and Retrieval
Population Dynamics

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Microbiology

Cite this

Piovia-Scott, J., Pope, K., Joy Worth, S., Rosenblum, E. B., Poorten, T., Refsnider, J., ... Foley, J. E. (2015). Correlates of virulence in a frog-killing fungal pathogen: Evidence from a California amphibian decline. ISME Journal, 9(7), 1570-1578. https://doi.org/10.1038/ismej.2014.241

Correlates of virulence in a frog-killing fungal pathogen : Evidence from a California amphibian decline. / Piovia-Scott, Jonah; Pope, Karen; Joy Worth, S.; Rosenblum, Erica Bree; Poorten, Thomas; Refsnider, Jeanine; Rollins-Smith, Louise A.; Reinert, Laura K.; Wells, Heather L.; Rejmanek, Dan; Lawler, Sharon; Foley, Janet E.

In: ISME Journal, Vol. 9, No. 7, 24.07.2015, p. 1570-1578.

Research output: Contribution to journalArticle

Piovia-Scott, J, Pope, K, Joy Worth, S, Rosenblum, EB, Poorten, T, Refsnider, J, Rollins-Smith, LA, Reinert, LK, Wells, HL, Rejmanek, D, Lawler, S & Foley, JE 2015, 'Correlates of virulence in a frog-killing fungal pathogen: Evidence from a California amphibian decline', ISME Journal, vol. 9, no. 7, pp. 1570-1578. https://doi.org/10.1038/ismej.2014.241
Piovia-Scott J, Pope K, Joy Worth S, Rosenblum EB, Poorten T, Refsnider J et al. Correlates of virulence in a frog-killing fungal pathogen: Evidence from a California amphibian decline. ISME Journal. 2015 Jul 24;9(7):1570-1578. https://doi.org/10.1038/ismej.2014.241
Piovia-Scott, Jonah ; Pope, Karen ; Joy Worth, S. ; Rosenblum, Erica Bree ; Poorten, Thomas ; Refsnider, Jeanine ; Rollins-Smith, Louise A. ; Reinert, Laura K. ; Wells, Heather L. ; Rejmanek, Dan ; Lawler, Sharon ; Foley, Janet E. / Correlates of virulence in a frog-killing fungal pathogen : Evidence from a California amphibian decline. In: ISME Journal. 2015 ; Vol. 9, No. 7. pp. 1570-1578.
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