Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure

Joan H. Skurnick, Paul Palumbo, Anthony DeVico, Barbara Shacklett, Fred T. Valentine, Michael Merges, Roberta Kamin-Lewis, Jiri Mestecky, Thomas Denny, George K. Lewis, Joan Lloyd, Robert Praschunus, Amanda Baker, Douglas F. Nixon, Sharon Stranford, Robert Gallo, Sten H. Vermund, Donald B. Louria

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Seventeen women who were persistently uninfected by human immunodeficiency virus type 1 (HIV-1), despite repeated sexual exposure, and 12 of their HIV-positive male partners were studied for antiviral correlates of nontransmission. Thirteen women had ≥1 immune response in the form of CD8 cell noncytotoxic HIV-1 suppressive activity, proliferative CD4 cell response to HIV antigens, CD8 cell production of macrophage inflammatory protein-1β, or ELISPOT assay for HIV-1-specific interferon-γ secretion. The male HIV-positive partners without AIDS had extremely high CD8 cell counts. All 8 male partners evaluated showed CD8 cell-related cytotoxic HIV suppressive activity. Reduced CD4 cell susceptibility to infection, neutralizing antibody, single-cell cytokine production, and local antibody in the women played no apparent protective role. These observations suggest that the primary protective factor is CD8 cell activity in both the HIV-positive donor and the HIV-negative partner. These findings have substantial implications for vaccine development.

Original languageEnglish (US)
Pages (from-to)428-438
Number of pages11
JournalJournal of Infectious Diseases
Volume185
Issue number4
DOIs
StatePublished - Feb 15 2002

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Fingerprint Dive into the research topics of 'Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure'. Together they form a unique fingerprint.

  • Cite this

    Skurnick, J. H., Palumbo, P., DeVico, A., Shacklett, B., Valentine, F. T., Merges, M., Kamin-Lewis, R., Mestecky, J., Denny, T., Lewis, G. K., Lloyd, J., Praschunus, R., Baker, A., Nixon, D. F., Stranford, S., Gallo, R., Vermund, S. H., & Louria, D. B. (2002). Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. Journal of Infectious Diseases, 185(4), 428-438. https://doi.org/10.1086/338830