Correction of a nucleotide-excision-repair mutation by human chromosome 19 in hamster-human hybrid cells

L. H. Thompson, C. L. Mooney, K. Burkhart-Schultz, A. V. Carrano, M. J. Siciliano

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

A UV-sensitive mutant line of CHO cells, UV20, was shown to be phenotypically corrected to resistance by fusion with human lymphocytes or fibroblasts. Only human chromosome 19 correlated with the DNA repair phenotype of resistant hybrid clones and their resistant or sensitive subclones. This study demonstrates the mapping of a human repair gene by direct selection of complementing hybrids in the presence of a DNA-damaging agent (mitomycin C).

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalSomatic Cell and Molecular Genetics
Volume11
Issue number1
DOIs
StatePublished - Jan 1985
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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